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Fenofibric acid

Base Information Edit
  • Chemical Name:Fenofibric acid
  • CAS No.:42017-89-0
  • Molecular Formula:C17H15ClO4
  • Molecular Weight:318.757
  • Hs Code.:2918990090
  • European Community (EC) Number:255-626-9
  • NSC Number:281318
  • UNII:BGF9MN2HU1
  • DSSTox Substance ID:DTXSID8041030
  • Nikkaji Number:J22.637H
  • Wikidata:Q27077290
  • NCI Thesaurus Code:C83804
  • RXCUI:24852
  • Pharos Ligand ID:SNSBPMWJJGML
  • Metabolomics Workbench ID:154648
  • ChEMBL ID:CHEMBL981
  • Mol file:42017-89-0.mol
Fenofibric acid

Synonyms:2-[4'-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid;2-[p-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid;FNF acid;LF 153;LF 178 acid;NSC 281318;Procetofenic acid;a-1081;2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid;Propanoic acid,2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-;

Suppliers and Price of Fenofibric acid
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Fenofibric Acid
  • 1g
  • $ 236.00
  • TRC
  • Fenofibric Acid
  • 5g
  • $ 240.00
  • TCI Chemical
  • Fenofibric Acid >98.0%(GC)(T)
  • 1g
  • $ 23.00
  • TCI Chemical
  • Fenofibric Acid >98.0%(GC)(T)
  • 5g
  • $ 76.00
  • SynQuest Laboratories
  • 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid
  • 1 g
  • $ 105.00
  • SynQuest Laboratories
  • 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid
  • 250 mg
  • $ 55.00
  • Sigma-Aldrich
  • Fenofibrate Related Compound B United States Pharmacopeia (USP) Reference Standard
  • 25mg
  • $ 1260.00
  • Sigma-Aldrich
  • Fenofibrate impurity B European Pharmacopoeia (EP) Reference Standard
  • f0048010
  • $ 190.00
  • Sigma-Aldrich
  • Fenofibric acid 95%
  • 1g
  • $ 50.50
  • Sigma-Aldrich
  • Fenofibric acid analytical standard
  • 10mg
  • $ 105.00
Total 147 raw suppliers
Chemical Property of Fenofibric acid Edit
Chemical Property:
  • Appearance/Colour:white to off-white solid 
  • Vapor Pressure:2.82E-10mmHg at 25°C 
  • Melting Point:177-179 °C 
  • Boiling Point:486.457 °C at 760 mmHg 
  • PKA:3.09±0.10(Predicted) 
  • Flash Point:248.001 °C 
  • PSA:63.60000 
  • Density:1.287 g/cm3 
  • LogP:3.81300 
  • Storage Temp.:-20°C Freezer 
  • Solubility.:Chloroform (Slightly), Methanol (Slightly) 
  • XLogP3:3.9
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:5
  • Exact Mass:318.0658866
  • Heavy Atom Count:22
  • Complexity:405
Purity/Quality:

99% *data from raw suppliers

Fenofibric Acid *data from reagent suppliers

Safty Information:
  • Pictogram(s): 2058973 
  • Hazard Codes:Xn,N 
  • Statements: 36/37/38-50/53-22 
  • Safety Statements: 26-36/37/39-61-60-24/25 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC(C)(C(=O)O)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
  • Recent ClinicalTrials:Antiangiogenic Therapy for Children With Recurrent Medulloblastoma, Ependymoma and ATRT
  • Uses Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-Iediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptorependent manner Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner. DPP4 inhibitor, antidiabetic
Technology Process of Fenofibric acid

There total 9 articles about Fenofibric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With water; triethylamine; lithium bromide; In acetonitrile; for 7h; Heating;
DOI:10.1016/j.tetlet.2007.02.029
Guidance literature:
benzyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate; With potassium hydroxide; In ethanol; for 16h; Heating / reflux;
With hydrogenchloride; In water; pH=1;
Guidance literature:
4-chloro-4'-hydroxybenzophenone; With sodium hydroxide; In butanone; at 50 ℃; for 1h;
2-bromo-2-methylpropionic acid; In butanone; at 50 ℃; for 16h;
DOI:10.1055/s-2004-829171
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