4'-Chloro-5-methoxy-3-biphenylylacetohydroxamic acid

Base Information

• Chemical Name: 4'-Chloro-5-methoxy-3-biphenylylacetohydroxamic acid
• CAS No.: 61888-70-8
• Molecular Formula: C₁₅H₁₄ClNO₃
• Molecular Weight: 291.734
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID50210894
• Wikidata: Q83085721
• ChEMBL ID: CHEMBL3244545
• Mol file: 61888-70-8.mol

Synonyms:BRN 2137964;61888-70-8;4'-Chloro-5-methoxy-3-biphenylylacetohydroxamic acid;(1,1'-Biphenyl)-3-acetamide, 4'-chloro-N-hydroxy-5-methoxy-;4'-Chloro-N-hydroxy-5-methoxy-(1,1'-biphenyl)-3-acetamide;CHEMBL3244545;DTXSID50210894;LS-44022

Chemical Property of 4'-Chloro-5-methoxy-3-biphenylylacetohydroxamic acid

Chemical Property:

• PSA: 62.05000
• Density: 1.285g/cm3
• LogP: 3.90380
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 291.0662210
• Heavy Atom Count: 20
• Complexity: 318

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)C2=CC=C(C=C2)Cl)CC(=O)NO

Technology Process of 4'-Chloro-5-methoxy-3-biphenylylacetohydroxamic acid

There total 6 articles about 4'-Chloro-5-methoxy-3-biphenylylacetohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-chlorophenyl)-3-buten-2-one (3160-40-5) → 2-(4'-Chloro-5-methoxy-biphenyl-3-yl)-N-hydroxy-acetamide (61888-70-8)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) NaOMe, MeOH, (ii) aq. NaOH, (iii) aq. HCl

2: POCl₃, Na₂CO₃ / toluene

3: Na / toluene

4: Br₂ / benzene

5: NH₂OH*HCl, NaOMe

With hydroxylamine hydrochloride; bromine; sodium methylate; sodium; sodium carbonate; trichlorophosphate; In toluene; benzene;

DOI:10.1021/jm00215a018

Reference yield:

5-(4-chlorophenyl)cyclohexane-1,3-dione (27463-38-3) → 2-(4'-Chloro-5-methoxy-biphenyl-3-yl)-N-hydroxy-acetamide (61888-70-8)

Guidance literature:

Multi-step reaction with 4 steps

1: POCl₃, Na₂CO₃ / toluene

2: Na / toluene

3: Br₂ / benzene

4: NH₂OH*HCl, NaOMe

With hydroxylamine hydrochloride; bromine; sodium methylate; sodium; sodium carbonate; trichlorophosphate; In toluene; benzene;

DOI:10.1021/jm00215a018

Reference yield:

[5-(4-Chloro-phenyl)-3-oxo-cyclohex-1-enyl]-acetic acid methyl ester (51367-59-0) → 2-(4'-Chloro-5-methoxy-biphenyl-3-yl)-N-hydroxy-acetamide (61888-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂ / benzene

2: NH₂OH*HCl, NaOMe

With hydroxylamine hydrochloride; bromine; sodium methylate; In benzene;

DOI:10.1021/jm00215a018

upstream raw materials:

(4'-Chloro-5-methoxy-biphenyl-3-yl)-acetic acid methyl ester

4-(4-chlorophenyl)-3-buten-2-one

5-(4-chlorophenyl)cyclohexane-1,3-dione

[5-(4-Chloro-phenyl)-3-oxo-cyclohex-1-enyl]-acetic acid methyl ester