6-Methylenedihydroepoxymorphine

Base Information

• Chemical Name: 6-Methylenedihydroepoxymorphine
• CAS No.: 3414-84-4
• Molecular Formula: C18H21NO2
• Molecular Weight: 283.3648
• DSSTox Substance ID: DTXSID20187741
• Nikkaji Number: J41.763G
• Wikipedia: 6-Methylenedihydrodesoxymorphine
• Wikidata: Q429449
• Mol file: 3414-84-4.mol

Synonyms:6-Methylenedihydroepoxymorphine;6-Methylenedihydrodesoxymorphine;BRN 0039900;3414-84-4;4,5-alpha-Epoxy-17-methyl-6-methylene morphinan-3-ol;Morphinan-3-ol, 4,5-alpha-epoxy-17-methyl-6-methylene-;4-27-00-02076 (Beilstein Handbook Reference);SCHEMBL17158170;DTXSID20187741;LS-91990;Q429449;4,5alpha-Epoxy-17-methyl-6-methylenemorphinan-3-ol;Morphinan-3-ol, 4,5-epoxy-17-methyl-6-methylene-, (5.alpha.)-

Chemical Property of 6-Methylenedihydroepoxymorphine

Chemical Property:

• Vapor Pressure: 8.71E-08mmHg at 25°C
• Boiling Point: 423.9°Cat760mmHg
• Flash Point: 210.2°C
• PSA: 32.70000
• Density: 1.3g/cm³
• LogP: 2.55530
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 283.157228913
• Heavy Atom Count: 21
• Complexity: 492

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=C)CC4
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=C)CC4

Technology Process of 6-Methylenedihydroepoxymorphine

There total 6 articles about 6-Methylenedihydroepoxymorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5α-epoxy-3-methoxymethoxy-17-methyl-6-methylene-morphinane (5141-67-3) → 6-Methylen-dihydrodesoxy-morphin (3414-84-4)

Guidance literature:

With acetic acid; at 90 ℃; for 40h;

DOI:10.1021/jm00319a001

Reference yield:

(4R,4aR,7aS,12bS)-9-methoxy-3-methyl-7-methylene-2,3,4,4a,-5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline (113222-66-5) → 6-Methylen-dihydrodesoxy-morphin (3414-84-4)

Guidance literature:

With pyridine hydrochloride;

DOI:10.1021/ja01578a040

Reference yield:

Hydrocodone (125-29-1) → 6-Methylen-dihydrodesoxy-morphin (3414-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: THF

2: pyridine hydrochloride

With tetrahydrofuran; pyridine hydrochloride;

DOI:10.1021/ja01578a040

upstream raw materials:

(4R,4aR,7aS,12bS)-9-methoxy-3-methyl-7-methylene-2,3,4,4a,-5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline

4,5α-epoxy-3-methoxymethoxy-17-methyl-6-methylene-morphinane

Hydrocodone

hydromorphone