Hydromorphone

Base Information

• Chemical Name: Hydromorphone
• CAS No.: 466-99-9
• Deprecated CAS: 18145-12-5,41376-02-7
• Molecular Formula: C17H19 N O3
• Molecular Weight: 285.343
• Hs Code.: 2939110014
• European Community (EC) Number: 207-383-5
• NSC Number: 19046
• UNII: Q812464R06
• DSSTox Substance ID: DTXSID8023133
• Nikkaji Number: J5.904H
• Wikipedia: Hydromorphone
• Wikidata: Q303646
• NCI Thesaurus Code: C62034
• RXCUI: 3423
• Pharos Ligand ID: JLGV9NTPDPX3
• Metabolomics Workbench ID: 42711
• ChEMBL ID: CHEMBL398707
• Mol file: 466-99-9.mol

Synonyms:Dihydromorphinone;Dilaudid;Hydromorphon;Hydromorphone;Hydromorphone Hydrochloride;Laudacon;Palladone

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Hydromorphone

Chemical Property:

• Vapor Pressure: 1.14E-09mmHg at 25°C
• Melting Point: 266-267°
• Refractive Index: 1.5400 (estimate)
• Boiling Point: 475.6°Cat760mmHg
• PKA: pKa 8.15 (Uncertain)
• Flash Point: 241.4°C
• PSA: 49.77000
• Density: 1.4g/cm³
• LogP: 1.56820
• Storage Temp.: ?20°C
• Water Solubility.: 1.931g/L(25 oC)
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 285.13649347
• Heavy Atom Count: 21
• Complexity: 494

Purity/Quality:

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4
• Recent ClinicalTrials: Comparison of Short-term Sustained-release Opioid in Open Abdominal Urologic Surgeries
• Recent EU Clinical Trials: Multicentre, randomized, open-label study to prove an additional
• Recent NIPH Clinical Trials: Examination of the effect of hydromorphone on cough
• General Description: Hydromorphone is a potent semisynthetic opioid used for pain management, particularly in cancer patients. Its metabolism involves the formation of various metabolites, which were isolated and identified from urine samples to better understand its pharmacokinetics and clinical implications. The study highlights the importance of analyzing hydromorphone's metabolic profile to ensure its safe and effective use in therapeutic settings.

Technology Process of Hydromorphone

There total 39 articles about Hydromorphone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dihydromorphine (509-60-4,13004-73-4,26626-12-0) → hydromorphone (466-99-9)

Guidance literature:

With D-glucose; In methanol; at 29 - 30 ℃; for 120h; Bacillus spec.;

Reference yield: 94.0%

8,14-dihydrooripavine (873087-79-7) → hydromorphone (466-99-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 1h;

Reference yield: 90.0%

MORPHIN (57-27-2) → hydromorphone (466-99-9)

Guidance literature:

MORPHIN; With sulfuric acid; In ethanol; water; for 0.166667h; Inert atmosphere;

In ethanol; water; at 65 - 90 ℃; Product distribution / selectivity;

upstream raw materials:

morphine hydrochloride

cyclohexanone

aluminum tri-tert-butoxide

toluene

Downstream raw materials:

hydromorphone hydrochloride

Refernces

Hydromorphone metabolites: Isolation and identification from pooled urine samples of a cancer patient

10.1080/00498250110119090

The study focused on the isolation and identification of hydromorphone metabolites from the urine samples of a cancer patient undergoing hydromorphone therapy for pain management. Hydromorphone, a potent semisynthetic opioid, was the primary compound of interest, and its metabolites were analyzed to understand its metabolic fate in the human body. The researchers used various chemicals in the study, including hydromorphone hydrochloride, morphine sulfate, Amberlite XAD-2 resin for urine sample processing, and reagents like palladium on activated carbon for synthesis. They also employed LC/MS/MS (liquid chromatography-tandem mass spectrometry) for the detection and identification of metabolites. The purpose of these chemicals was to synthesize known metabolites for comparison with those found in the patient's urine and to develop a method for isolating and identifying hydromorphone and its metabolites. The study aimed to provide a comprehensive profile of hydromorphone metabolism, which is crucial for understanding its efficacy and safety in clinical use.