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Technology Process of Hydromorphone

Hydromorphone

Base Information Edit
  • Chemical Name:Hydromorphone
  • CAS No.:466-99-9
  • Deprecated CAS:18145-12-5,41376-02-7
  • Molecular Formula:C17H19 N O3
  • Molecular Weight:285.343
  • Hs Code.:2939110014
  • European Community (EC) Number:207-383-5
  • NSC Number:19046
  • UNII:Q812464R06
  • DSSTox Substance ID:DTXSID8023133
  • Nikkaji Number:J5.904H
  • Wikipedia:Hydromorphone
  • Wikidata:Q303646
  • NCI Thesaurus Code:C62034
  • RXCUI:3423
  • Pharos Ligand ID:JLGV9NTPDPX3
  • Metabolomics Workbench ID:42711
  • ChEMBL ID:CHEMBL398707
  • Mol file:466-99-9.mol
Hydromorphone

Synonyms:Dihydromorphinone;Dilaudid;Hydromorphon;Hydromorphone;Hydromorphone Hydrochloride;Laudacon;Palladone

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Hydromorphone Edit
Chemical Property:
  • Vapor Pressure:1.14E-09mmHg at 25°C 
  • Melting Point:266-267° 
  • Refractive Index:1.5400 (estimate) 
  • Boiling Point:475.6°Cat760mmHg 
  • PKA:pKa 8.15 (Uncertain) 
  • Flash Point:241.4°C 
  • PSA：49.77000 
  • Density:1.4g/cm3 
  • LogP:1.56820 
  • Storage Temp.:?20°C 
  • Water Solubility.:1.931g/L(25 oC) 
  • XLogP3:1.8
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:0
  • Exact Mass:285.13649347
  • Heavy Atom Count:21
  • Complexity:494
Purity/Quality:
Safty Information:
  • Pictogram(s): F,T 
  • Hazard Codes:F,T 
  • Statements: 11-23/24/25-39/23/24/25 
  • Safety Statements: 7-16-36/37-45 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4
  • Isomeric SMILES:CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4
  • Recent ClinicalTrials:Comparison of Short-term Sustained-release Opioid in Open Abdominal Urologic Surgeries
  • Recent EU Clinical Trials:Multicentre, randomized, open-label study to prove an additional
  • Recent NIPH Clinical Trials:Examination of the effect of hydromorphone on cough
  • Description Hydromorphone (Item No. 15463) is an analytical reference material categorized as an opioid. It is a metabolite of morphine (Item Nos. 15464 | ISO60147). Like other opioid analgesics, hydromorphone is commonly abused. Hydromorphone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
  • Uses Hydromorphone, a potent opioid, is used mainly in the palliative care seing or in patients who are not opioid naive. It can be useful if considering opioid rotation. Hydromorphone 1.3mg is approximately equianalgesic to morphine 10 mg. Both immediate- and sustained-release preparations are available. Meperidine (pethidine) is available as parenteral and oral preparations. There is no evidence that this opioid provides any advantage over morphine, such as treatment of colicky-type pain. Its analgesic action is fairly short, but the metabolite normeperidine can accumulate (t1/2 ~ 15h) if repeated doses are given and especially if there is renal dysfunction. Normeperidine is a CNS stimulant and can cause seizures. Its clearance is significantly reduced in hepatic disease. Chronic use may result in enzyme induction and an increase in normeperidine plasma concentrations. Its metabolism is decreased by the oral contraceptive pill. Meperidine has other significant effects related to activity at non-opioid receptors. For example, its atropine-like action may cause a tachycardia, in addition to direct myocardial depression at high doses. It was used originally as a bronchodilator. It can also reduce shivering related to hypothermia or epidural anaesthesia, although the mechanism for this is not fully understood. Meperidine also has a local anaesthetic-like membrane stabilising action.
  • Biological Functions Hydromorphone is eight times as potent as morphine but has less bioavailability following oral administration. Its side effects do not differ from those of morphine but are more intense. Hydromorphone is indicated for use in severe pain and in high doses for relief of pain in opioid-addicted patients.
Technology Process of Hydromorphone

There total 39 articles about Hydromorphone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dihydromorphine
509-60-4,13004-73-4,26626-12-0

dihydromorphine

hydromorphone
466-99-9

hydromorphone

Guidance literature:
With D-glucose; In methanol; at 29 - 30 ℃; for 120h; Bacillus spec.;

Reference yield: 94.0%

8,14-dihydrooripavine
873087-79-7

8,14-dihydrooripavine

hydromorphone
466-99-9

hydromorphone

Guidance literature:
With hydrogenchloride; In ethanol; at 20 ℃; for 1h;

Reference yield: 90.0%

MORPHIN
57-27-2

MORPHIN

hydromorphone
466-99-9

hydromorphone

Guidance literature:
MORPHIN; With sulfuric acid; In ethanol; water; for 0.166667h; Inert atmosphere;
In ethanol; water; at 65 - 90 ℃; Product distribution / selectivity;
upstream raw materials:

morphine hydrochloride

cyclohexanone

aluminum tri-tert-butoxide

toluene

Downstream raw materials:

carbonic acid ethyl ester-(4,5α-epoxy-6α-hydroxy-17-methyl-6β-phenyl-morphinan-3-yl ester)

hydromorphone hydrochloride

Refernces Edit

Total 8 Pictures about this product