2-FLUOROPALMITIC ACID

Base Information

• Chemical Name: 2-FLUOROPALMITIC ACID
• CAS No.: 16518-94-8
• Molecular Formula: C₁₆H₃₁FO₂
• Molecular Weight: 274.419
• Hs Code.: 2915900090
• Mol file: 16518-94-8.mol

Synonyms:2-Fluoropalmiticacid; NSC 158288

Chemical Property of 2-FLUOROPALMITIC ACID

Chemical Property:

• Vapor Pressure: 1.08E-06mmHg at 25°C
• Boiling Point: 376.1°Cat760mmHg
• PKA: 2.70±0.21(Predicted)
• Flash Point: 181.3°C
• PSA: 37.30000
• Density: 0.936g/cm³
• LogP: 5.50030
• Storage Temp.: −20°C
• Solubility.: Soluble in DMSO

Purity/Quality:

99%min ^*data from raw suppliers

2-fluoro Palmitic Acid ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUOROPALMITIC ACID

There total 4 articles about 2-FLUOROPALMITIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxypalmitic acid (764-67-0,10067-06-8) + p-toluenesulfonyl chloride (98-59-9) → 2-fluorohexadecanoic acid (16518-94-8,89270-22-4)

Guidance literature:

With potassium hydroxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; pyridine; hydrochloric acid-methanol; water; water ethanol; acetonitrile;

Reference yield:

2-Fluoro-2-tetradecyl-malonic acid diethyl ester (16518-89-1) → 2-fluorohexadecanoic acid (16518-94-8,89270-22-4)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jm00314a013

Reference yield:

diethyl 2-tetradecylmalonate (54580-47-1) → 2-fluorohexadecanoic acid (16518-94-8,89270-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) Na, toluene, (ii) ClO₃F

2: aq. HCl

With hydrogenchloride;

DOI:10.1021/jm00314a013

upstream raw materials:

2-Fluoro-2-tetradecyl-malonic acid diethyl ester

diethyl 2-tetradecylmalonate

2-hydroxypalmitic acid

p-toluenesulfonyl chloride

Refernces

• 1、 -. "Organic acids as catalysts for the erosion of polymers". . . Retrieved 2008/06/13.