54580-47-1

Upstream product

• 855390-02-2 tetradecyl-oxalacetic acid diethyl ester 
• 628-97-7 hexadecanoic acid ethyl ester 
• 95-92-1 oxalic acid diethyl ester 
• 112-71-0 1-Bromotetradecane 
• 105-53-3 diethyl malonate 
• 996-82-7 sodium diethylmalonate 

Downstream Products

• 4475-23-4 1,1-pentadecanedicarboxylic acid 
• 16518-94-8 2-fluorohexadecanoic acid 
• 73756-39-5 2-tetradecyloctadecanoic acid 
• 57-10-3 1-hexadecylcarboxylic acid 
• 41240-22-6 2-tetradecyl-glutaric acid 

Relevant academic research and scientific papers

Bithiophenesulfonamide Building Block for π-Conjugated Donor-Acceptor Semiconductors

We report here π-conjugated small molecules and polymers based on the new π-acceptor building block, bithiophenesulfonamide (BTSA). Molecular orbital computations and optical, electrochemical, and crystal structure analyses illuminate the architecture and electronic structure of the BTSA unit versus other acceptor building blocks. Field-effect transistors and photovoltaic cells demonstrate that BTSA is a promising unit for the construction of π-conjugated semiconducting materials.

NOVEL XYLENE-BASED AMPHIPHILIC COMPOUND AND USE THEREOF

The present invention relates to a xylene-based amphiphilic compound, a method for preparing the same, and a method for extracting, solubilizing, stabilizing or crystallizing a membrane protein using the same. By using the xylene-based compound according to the present invention, a membrane protein may be stably stored in an aqueous solution for a long time, and may be applied in functional and structural analyses. The structural and functional analysis of the membrane protein is one of the fields of highest interest in biology and chemistry, and the xylene-based compound according to the present invention can be applied in research on protein structure that is closely related to development of a new drug.

NOVEL MESITYLENE-CORED AMPHIPHILES AND USES THEREOF

The present invention relates to a mesitylene-cored amphiphile, a method of preparing the same and a method of extraction, solubilization, stabilization, crystallization or analysis of a membrane protein using the same. When a mesitylene-cored compound according to the present invention is used, membrane proteins can be stored in a stable conformation for a long time in an aqueous solution in comparison with conventional compounds, by which the membrane proteins are usable in both functional and structural analyses thereof. The functional and structural analyses of membrane proteins are one of the fields that are most spotlighted in current biology and chemistry. The present invention can be used to research on a protein structure closely related to new drug development.

Bithiophene sulfonamide-based molecular and polymeric semiconductors

The present invention relates to new semiconducting compounds having at least one optionally substituted bithiophene sulfonamide moiety. The compounds disclosed herein can exhibit high carrier mobility and/or efficient light absorption/emission characteristics, and can possess certain processing advantages such as solution-processability and/or good stability at ambient conditions.

Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy

Detergents serve as useful tools for membrane protein structural and functional studies. Their amphipathic nature allows detergents to associate with the hydrophobic regions of membrane proteins whilst maintaining the proteins in aqueous solution. However

General synthesis and physicochemical characterisation of a series of peptide-mimic lysine-based amino-functionalised lipids

A series of novel malonic acid diamides (second generation) with two long hydrophobic alkyl chains and an alkaline polar head group was synthesised and characterised as a new class of amino-functionalised lipids. These peptide-mimic lipids are suitable for polynucleotide transfer. The lipids bear a novel backbone consisting of a lysine unit and a malonic acid unit. Six different head-group structures, which vary in size and number of amino groups that can be protonated, were attached to the backbone structure. Furthermore, different alkyl chains were used to build the lipophilic part (namely tetradecyl, hexadecyl, and oleyl). Phase transitions of the new compounds in aqueous dispersions at pHa 10 were analysed and discussed in terms of head group and alkyl chain variations. The shape and size of the formed aggregates of selected lipid dispersions were investigated by dynamic light scattering and transmission electron microscopy. Copycats: Malonic acid diamides, a new class of amino-functionalised lipids, have been synthesised and characterised. These peptide-mimic lipids are suitable for polynucleotide transfer. Six head-group structures, which vary in size and number of amino groups, are used. The modularly composed synthesis of the backbone allows easy alkyl-chain variation (see figure). Phase transitions are discussed in terms of head-group and alkyl-chain variations. Copyright

Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)

A novel class of KAT modulators (long chain alkylidenemalonates, LoCAMs) has been identified. Variations of the alkyl chain length can change the activity profile from inhibition of both KAT3A/KAT2B (as derivative 2a) to the peculiar profile of pentadecylidenemalonate 1b, the first activator/inhibitor of histone acetyltransferases. Together with the powerful apoptotic effect (particularly notable if considering that anacardic acid and other KAT inhibitors are not cell permeable) appoint them as valuable biological tools to understand the mechanisms of lysine acetyltransferases.

LPA RECEPTOR AGONISTS AND ANTAGONISTS

Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.

Synthesis and antibacterial properties of novel hydrolyzable cationic amphiphiles. Incorporation of multiple head groups leads to impressive antibacterial activity

Two sets of novel multiheaded cationic amphiphiles bearing one, two, and three trimethyl-ammonium headgroups (T1, T2, and T3) and pyridinium headgroups (P1, P2, and P3), have been synthesized and tested for antimicrobial activities against both Gram-positive and Gram-negative bacteria. The multicationic headgroups in these amphiphiles were attached covalently via scissile ester-type linkages. The results were compared with those for known surface-active, nonhydrolyzable compounds cetyltrimethylammonium bromide (CTAB) and cetylpyridinium bromide (CPB). The killing effects of the new single-headed amphiphiles (T1 and P1) were lower than those of CTAB and CPB, but with an increase in the number of headgroups in the amphiphiles, the killing effects increased for both sets of compounds. It was found that amphiphiles with triple headgroups (T3 and P3) were most active among all the amphiphiles, whereas amphiphile P1 had a very poor killing effect on both types of bacteria. The multiheaded pyridinium amphiphiles were more active compared to their trimethylammonium counterparts. The time needed to kill bacteria with multiheaded amphiphiles was significantly less than that of single-headed amphiphiles. Owing to the presence of a cleavable ester moiety, these new amphiphiles are hydrolyzed spontaneously at physiological conditions. This property enables them to be readily metabolized and therefore have the potential to be superior disinfectants and antiseptics for food and body surfaces.

New types of nonionic surfactants with sugar head groups

The head group/lipophilic tail ratio is used to categorize amphiphilic compounds into different types. Some representatives of the 2/1 type with two sugar head groups and one lipophilic chain, namely compounds 6a-d, were synthesized from readily available precursors. Similarly, from 2,3-di-O-alkyl and 1,3-di-O-alkyl derivatives of D-threitol 2/2-type amphiphiles 13a-d, 15a-d and 20a-d, respectively, were obtained. Due to the different spatial demand of the sugar moieties relative to the lipophilic part, surface tension (σ) and critical micelle concentration (cmc) are clearly distinguished in these different structural types of nonionic surfactants. VCH Verlagsgesellschaft mbH, 1996.