Frakefamide

Base Information

Chemical Name:Frakefamide
CAS No.:188196-22-7
Molecular Formula:C30H34FN5O5
Molecular Weight:563.6199
Hs Code.:
UNII:DM32B4GU70
DSSTox Substance ID:DTXSID701030318
Wikipedia:Frakefamide
Wikidata:Q5477806
NCI Thesaurus Code:C77290
ChEMBL ID:CHEMBL3989481
Mol file:188196-22-7.mol

Synonyms:frakefamide;H-Tyr-(D)-Ala-(pF)Phe-Phe-NH2 hydrochloride

Suppliers and Price of Frakefamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
FRAKEFAMIDE 95.00%
5MG
$ 504.58

Total 5 raw suppliers

Chemical Property of Frakefamide

Chemical Property:

Vapor Pressure:3.47E-34mmHg at 25°C
Boiling Point:897.9°Cat760mmHg
Flash Point:496.8°C
PSA：176.64000
Density:1.295g/cm³
LogP:3.41940
XLogP3:1.4
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:13
Exact Mass:563.25439736
Heavy Atom Count:41
Complexity:869

Purity/Quality:

99% ^*data from raw suppliers

FRAKEFAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(=O)NC(CC1=CC=C(C=C1)F)C(=O)NC(CC2=CC=CC=C2)C(=O)N)NC(=O)C(CC3=CC=C(C=C3)O)N
Isomeric SMILES:C[C@H](C(=O)N[C@@H](CC1=CC=C(C=C1)F)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N)NC(=O)[C@H](CC3=CC=C(C=C3)O)N

Technology Process of Frakefamide

There total 13 articles about Frakefamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: CBz-Tyr-D-Ala-Phe(F)-Phe-NH₂

: 188196-22-7
L-tyrosyl-D-alanyl-p-fluoro-L-phenylalanyl-L-phenylalaninamide

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In N,N-dimethyl-formamide; at 30 ℃; for 2.25h; under 2280.15 Torr; Large scale;
DOI:10.1021/op020060k

Reference yield:

: 1164-16-5
Z-L-Tyr-OH

: 188196-22-7
L-tyrosyl-D-alanyl-p-fluoro-L-phenylalanyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine / N,N-dimethyl-formamide / -15 - -5 °C / Large scale

2.1: 4-methyl-morpholine / N,N-dimethyl-formamide / -10 - -5 °C / Large scale

2.2: 4 h / 30 °C / Large scale

3.1: hydrogen; 5%-palladium/activated carbon / N,N-dimethyl-formamide / 2.25 h / 30 °C / 2280.15 Torr / Large scale

With 4-methyl-morpholine; 5%-palladium/activated carbon; hydrogen; In N,N-dimethyl-formamide;
DOI:10.1021/op020060k

Reference yield:

: CBz-Phe(F)-Phe-OMe

: 188196-22-7
L-tyrosyl-D-alanyl-p-fluoro-L-phenylalanyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / methanol

2: hydrogen; 5%-palladium/activated carbon / N,N-dimethyl-formamide / 2 h / 30 °C / 2280.15 Torr / Large scale

3: isobutyl chloroformate; 4-methyl-morpholine / acetone

4: hydrogen; 5%-palladium/activated carbon / N,N-dimethyl-formamide / 2.25 h / 30 °C / 2280.15 Torr / Large scale

With 4-methyl-morpholine; 5%-palladium/activated carbon; ammonia; hydrogen; isobutyl chloroformate; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/op020060k