5-Nitro-6-p-chlorophenylimidazo(2,1-b)thiazole

Base Information

• Chemical Name: 5-Nitro-6-p-chlorophenylimidazo(2,1-b)thiazole
• CAS No.: 106671-89-0
• Molecular Formula: C₁₁H₆ClN₃O₂S
• Molecular Weight: 279.707
• Hs Code.: 2934100090
• Mol file: 106671-89-0.mol

Synonyms:Imidazo(2,1-b)thiazole, 6-(p-chlorophenyl)-5-nitro-; 6-(p-Chlorophenyl)-5-nitroimidazo(2,1-b)thiazole; BRN 1082443; CCRIS 2486; 6-(4-Chlorophenyl)-5-nitroimidazo(2,1-b)thiazole; 6-(4-chlorophenyl)-5-nitroimidazo[2,1-b][1,3]thiazole

Chemical Property of 5-Nitro-6-p-chlorophenylimidazo(2,1-b)thiazole

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 91.36000
• Density: 1.65g/cm³
• LogP: 4.14760

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Nitro-6-p-chlorophenylimidazo(2,1-b)thiazole

There total 2 articles about 5-Nitro-6-p-chlorophenylimidazo(2,1-b)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-[2-(4-chloro-phenyl)-2-oxo-ethyl]-thiazolium; bromide → 6-(4-chloro-phenyl)-5-nitro-imidazo[2,1-b]thiazole (106671-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOAc

2: (i) HNO₃, dioxane, (ii) H₂SO₄

With sodium acetate;

Reference yield:

6-(4'-chlorophenyl)imidazo<2,1-b>thiazole (7025-30-1) → 6-(4-chloro-phenyl)-5-nitro-imidazo[2,1-b]thiazole (106671-89-0)

Guidance literature:

Multistep reaction; (i) HNO₃, dioxane, (ii) H₂SO₄;

Reference yield:

6-(4-chloro-phenyl)-5-nitro-imidazo[2,1-b]thiazole (106671-89-0) → 6-(4-chloro-phenyl)-imidazo[2,1-b]thiazol-5-ylamine (91183-08-3)

Guidance literature:

With zinc; In acetic acid;

upstream raw materials:

6-(4'-chlorophenyl)imidazo<2,1-b>thiazole

Downstream raw materials:

6-(4-chloro-phenyl)-imidazo[2,1-b]thiazol-5-ylamine

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