7025-30-1

Usage

Uses

Used in Pharmaceutical Industry:
6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole is used as an intermediate in the synthesis of CITCO, a cell-permeable imidazothiazole compound that acts as a CAR agonist. This makes it valuable in the development of pharmaceuticals targeting the CAR pathway, which is involved in the regulation of drug metabolism, detoxification, and cell proliferation.
Used in Drug Synthesis:
6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole is utilized in the synthesis of CITCO, a compound with potential therapeutic applications. Its role as an intermediate allows for the creation of new drugs that can modulate the activity of the constitutive androstane receptor, potentially leading to treatments for various diseases and conditions.
Used in Research Applications:
6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole is also used in research settings to study the role of CAR in cellular processes. By understanding the interactions between 6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE and the receptor, researchers can gain insights into the development of new therapeutic strategies and drug candidates targeting the CAR pathway.

Upstream product

• 96-50-4 2-thiazolylamine 
• 99-91-2 para-chloroacetophenone 
• 518068-75-2 2,4-dinitro-benzenesulfonic acid 2-(4-chloro-phenyl)-2-oxo-ethyl ester 
• 25917-49-1 1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 106671-89-0 6-(4-chloro-phenyl)-5-nitro-imidazo[2,1-b]thiazole 
• 139359-90-3 (E)-6-(4-chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde oxime 
• 82588-59-8 5-hydroxymethyl-6-p-chlorophenylimidazo<2,1-b>thiazole 
• 82588-41-8 5-Formyl-6-p-chlorophenylimidazo<2,1-b>thiazole 

Relevant academic research and scientific papers

Stereoisomerization of human constitutive androstane receptor agonist CITCO

CITCO (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl) oxime) is a widely used agonist of the human constitutive androstane receptor (hCAR), a key hepatic xenobiotic sensor protein with emerging therapeutic indications.

New imidazo[2,1-: B] thiazole-based aryl hydrazones: Unravelling their synthesis and antiproliferative and apoptosis-inducing potential

Herein, we have designed and synthesized new imidazo[2,1-b]thiazole-based aryl hydrazones (9a-w) and evaluated their anti-proliferative potential against a panel of human cancer cell lines. Among the synthesized compounds, 9i and 9m elicited promising cytotoxicity against the breast cancer cell line MDA-MB-231 with IC50 values of 1.65 and 1.12 μM, respectively. Cell cycle analysis revealed that 9i and 9m significantly arrest MDA-MB-231 cells in the G0/G1 phase. In addition, detailed biological studies such as annexin V-FITC/propidium iodide, DCFH-DA, JC-1 and DAPI staining assays revealed that 9i and 9m triggered apoptosis in MDA-MB-213 cells. Overall, the current work demonstrated the cytotoxicity and apoptosis-inducing potential of 9i and 9m in breast cancer cells and suggested that they could be explored as promising antiproliferative leads in the future. This journal is

SELECTIVE LIGANDS OF HUMAN CONSTITUTIVE ANDROSTANE RECEPTOR

The present invention provides a structurally novel class of heterocyclic compounds of general formula I wherein L1 is heteroaryl and L2 is heteroaryl or aryl. The novel compounds are useful in a method of prevention or treatment of a condition which is m

Sodium Salts (NaI/NaBr/NaCl) for the Halogenation of Imidazo-Fused Heterocycles

We report herein an effective method for the halogenation of imidazo-fused heterocycles using readily available sodium salts (NaCl/NaBr/NaI) as halogen source and K2S2O8 (or) oxone as promoter. A variety of C-3 halogenated imidazo[1,2-a]pyridines and benzo[d]imidazo[2,1-b]thiazoles were obtained in good to excellent yields. The present method of halogenation has been also extended to 2-aminopyridines, 2-aminopyrimidine, indole, and isoquinoline with moderate to excellent yields.

DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor

The constitutive androstane receptor (CAR) is a xenobiotic sensor governing the transcription of genes involved in drug disposition, energy homeostasis, and cell proliferation. However, currently available human CAR (hCAR) agonists are nonselective, which

Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors

A series of new triazole fused imidazo[2,1-b]thiazole hybrids (9a–u) were designed, synthesized and evaluated as antimicrobial agents. Compounds 9c, 9d, 9e, 9j and 9l showed promising broad spectrum antimicrobial activity. Further, compound 9c exhibited s

Hypervalent iodine(iii) sulfonate mediated synthesis of 6-arylimidazo[2,1-b]thiazoles in liquid PEG-400

PEG-400[poly(ethylene glycol-400)] is used as reaction medium in the one-pot synthesis of 6-arylimidazo[ 2,1-b]thiazoles by reaction with aryl ketones, hypervalent iodine(III) sulfonate and 2-aminothiazole. Significant rate enhancements and improved yield

IMIDAZOPYRIDINE COMPOUNDS

The invention relates to compounds of formula (I): and their pharmaceutically acceptable salts and solvates, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.

Hypervalent iodine in the synthesis of bridgehead heterocycles: A facile route to the synthesis of 6-arylimidazo[2,1-b]thiazoles using [hydroxy(tosyloxy)iodo]benzene

α-Tosyloxyketones (2), readily accessible through hypervalent iodine oxidation of enolizable ketones (1) using [hydroxy(tosyloxy)iodo]benzene (HTIB) in acetonitrile, exclusively generates the 6-arylimidazo[2,1-b]thiazoles (4) on treatment with commerciall