diphenyl(2-phenylethyl)phosphane oxide

Base Information

• Chemical Name: diphenyl(2-phenylethyl)phosphane oxide
• CAS No.: 3582-84-1
• Molecular Formula: C20H19OP
• Molecular Weight: 306.344
• Mol file: 3582-84-1.mol

Synonyms:

Chemical Property of diphenyl(2-phenylethyl)phosphane oxide

Chemical Property:

• Vapor Pressure: 1.91E-07mmHg at 25°C
• Boiling Point: 437.5°Cat760mmHg
• Flash Point: 218.4°C
• Density: 1.14g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenyl(2-phenylethyl)phosphane oxide

There total 50 articles about diphenyl(2-phenylethyl)phosphane oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

dihydrocinnamonitrile (645-59-0) + Diphenylphosphine oxide (4559-70-0) → (2-phenylethyl)diphenylphosphine oxide (3582-84-1)

Guidance literature:

With potassium tert-butylate; nickel(I) chloride; In 1,4-dioxane; at 120 ℃; for 16h; Inert atmosphere; Glovebox; Schlenk technique;

Reference yield: 92.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + Diphenylphosphine oxide (4559-70-0) → (2-phenylethyl)diphenylphosphine oxide (3582-84-1)

Guidance literature:

With pyridine; lanthanum tris(N,N-dimethylbenzylamine); at 80 ℃; for 16h; Temperature; regioselective reaction; Glovebox;

DOI:10.1021/acs.organomet.9b00549

Reference yield: 88.0%

4-methyl-N'-(2-phenylethylidene)benzenesulfonohydrazide (17336-58-2) + Diphenylphosphine oxide (4559-70-0) → (2-phenylethyl)diphenylphosphine oxide (3582-84-1)

Guidance literature:

With copper(l) iodide; caesium carbonate; In 1,2-dimethoxyethane; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1002/adsc.201200295

upstream raw materials:

phenyllithium

1-phenyl-octahydro-1-phospha-2,3-cyclo-dicyclopropa[a,cd]pentalene 1-oxide

(2-phenylethyl)diphenylphosphane

phenylacetic acid

Downstream raw materials:

(2R,3R)-2-(Diphenyl-phosphinoyl)-3-methyl-1-phenyl-pentan-3-ol

(2R,3S)-2-(Diphenyl-phosphinoyl)-3-methyl-1-phenyl-pentan-3-ol

1,3-diphenyl-2-(diphenylphosphinoyl)propan-1-one

(2-phenylethyl)diphenylphosphane

Refernces

• 1、 Feng, Jie,Zhang, Qiaoling,Li, Fuhai,Yang, Lu,Kuchukulla, Ratnakar Reddy,Zeng, Qingle. "Potassium tert -Butoxide Mediated Reductive C-P Cross-Coupling of Arylvinyl Sulfides through C-S Bond Cleavage". . p. 224 - 228. Retrieved 2020/10/30.
• 2、 Zhang, Mengyue,Ma, Zhichao,Du, Hongguang,Wang, Zhiqian. "Palladium-catalyzed C(sp3)–P(III) bond formation reaction with acylphosphines as phosphorus source". supporting information. . Retrieved 2020/06/29.