4-Methyl-N-(4-methylphenyl)benzenesulfonamide

Base Information

• Chemical Name: 4-Methyl-N-(4-methylphenyl)benzenesulfonamide
• CAS No.: 599-86-0
• Molecular Formula: C14H15 N O2 S
• Molecular Weight: 261.345
• Hs Code.: 2935009090
• European Community (EC) Number: 209-975-9
• NSC Number: 49574,2219
• DSSTox Substance ID: DTXSID70208612
• Nikkaji Number: J30.832C
• Wikidata: Q83082704
• ChEMBL ID: CHEMBL181965
• Mol file: 599-86-0.mol

Synonyms:599-86-0;4-Methyl-N-(4-methylphenyl)benzenesulfonamide;N-(p-Tolyl)-p-toluenesulphonamide;Benzenesulfonamide, 4-methyl-N-(4-methylphenyl)-;4-Methyl-N-(p-tolyl)benzenesulfonamide;EINECS 209-975-9;N-(p-Toluene sulfonyl)-p-toluidide;AI3-22944;NSC2219;CHEMBL181965;SCHEMBL2005010;4'-Methyl-p-toluenesulfoanilide;DTXSID70208612;N-(p-Tolyl)-p-toluenesulfonamide;BDBM237281;NSC 2219;NSC-2219;NSC49574;MFCD00441423;NSC 49574;NSC-49574;STK499588;AKOS000383118;UPCMLD0ENAT5427784:001;N-(4-Methylphenyl)-p-toluenesulfonamide;Carbonic anhydrase inhibitors (CAIs), 1;4-Methyl-N-(4-methylphenyl)benzenesulfonamide #;4-[[(4-METHYLBENZENE)SULFONYL]AMINO]TOLUENE;Z45633626

Chemical Property of 4-Methyl-N-(4-methylphenyl)benzenesulfonamide

Chemical Property:

• Vapor Pressure: 9.97E-07mmHg at 25°C
• Boiling Point: 403.7°Cat760mmHg
• Flash Point: 198°C
• PSA: 54.55000
• Density: 1.237g/cm³
• LogP: 4.25800
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 261.08234989
• Heavy Atom Count: 18
• Complexity: 345

Purity/Quality:

99% ^*data from raw suppliers

4-METHYL-N-(4-METHYLPHENYL)BENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)C

Technology Process of 4-Methyl-N-(4-methylphenyl)benzenesulfonamide

There total 71 articles about 4-Methyl-N-(4-methylphenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-toluidine (106-49-0,12221-03-3) + p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N-(4-methylphenyl)benzenesulfonamide (599-86-0)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.3109/14756366.2011.617745

Reference yield: 99.0%

4-toluenesulfonyl azide (941-55-9) + 4-methylphenylboronic acid (5720-05-8) → 4-methyl-N-(4-methylphenyl)benzenesulfonamide (599-86-0)

Guidance literature:

With copper(l) chloride; In methanol; at 20 ℃; for 0.5h;

DOI:10.1021/ol403717

Reference yield: 97.0%

p-toluidine (106-49-0,12221-03-3) + para-thiocresol (106-45-6) → 4-methyl-N-(4-methylphenyl)benzenesulfonamide (599-86-0)

Guidance literature:

para-thiocresol; With dihydrogen peroxide; zirconium(IV) chloride; In acetonitrile; at 25 ℃;

p-toluidine; With pyridine; In acetonitrile; at 25 ℃; for 0.0333333h; chemoselective reaction;

DOI:10.1016/j.tetlet.2010.07.056

upstream raw materials:

sodium acetate

p-toluidine

p-toluenesulfonyl chloride

C₁₄H₁₉N₃O₃S

Downstream raw materials:

toluene-4-sulfonic acid-(N-ethyl-p-toluidide)

N-(2-chloro-4-methylphenyl)-4-methylbenzenesulfonamide

4-Methyl-N-phenylacetyl-N-p-tolyl-benzenesulfonamide

N-((E)-But-2-enoyl)-4-methyl-N-p-tolyl-benzenesulfonamide