2-Methoxy-3,5-xylenol

Base Information

• Chemical Name: 2-Methoxy-3,5-xylenol
• CAS No.: 2785-85-5
• Molecular Formula: C9H12 O2
• Molecular Weight: 152.1904
• UNII: P739F6M34M
• DSSTox Substance ID: DTXSID90182162
• Wikidata: Q27286308
• Mol file: 2785-85-5.mol

Synonyms:2-Methoxy-3,5-xylenol;2-methoxy-3,5-dimethylphenol;2785-85-5;3,5-Xylenol, 2-methoxy-;UNII-P739F6M34M;P739F6M34M;Phenol, 2-methoxy-3,5-dimethyl-;4,6-Dimethylguajacol;SCHEMBL658125;2,4-Dimethyl-6-hydroxyanisole;DTXSID90182162;NAPGLDHBHXOYMM-UHFFFAOYSA-N;PHENOL, 3,5-DIMETHYL-2-METHOXY-;E97828;Q27286308

Chemical Property of 2-Methoxy-3,5-xylenol

Chemical Property:

• Vapor Pressure: 0.0228mmHg at 25°C
• Boiling Point: 241.7°Cat760mmHg
• Flash Point: 102.5°C
• Density: 1.053g/cm³
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 125

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)O)OC)C

Technology Process of 2-Methoxy-3,5-xylenol

There total 7 articles about 2-Methoxy-3,5-xylenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethyl-6-nitrophenol (14452-34-7) → 2-methoxy-3,5-dimethylphenol (2785-85-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 2 h / 70 °C

2: stannous chloride, hydrochloric acid / ethanol

With hydrogenchloride; sodium hydroxide; tin(ll) chloride; In methanol; ethanol;

DOI:10.3891/acta.chem.scand.43-0044

Reference yield:

4,6-dimethyl-2-nitroanisole (69051-75-8) → 2-methoxy-3,5-dimethylphenol (2785-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1: stannous chloride, hydrochloric acid / ethanol

With hydrogenchloride; tin(ll) chloride; In ethanol;

DOI:10.3891/acta.chem.scand.43-0044

Reference yield:

2,4-Xylenol (105-67-9) → 2-methoxy-3,5-dimethylphenol (2785-85-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium nitrate, sulfuric acid, acetic acid / 3 h

2: sodium hydroxide / methanol / 2 h / 70 °C

3: stannous chloride, hydrochloric acid / ethanol

With hydrogenchloride; sodium hydroxide; sodium nitrate; sulfuric acid; acetic acid; tin(ll) chloride; In methanol; ethanol;

DOI:10.3891/acta.chem.scand.43-0044

upstream raw materials:

2-methoxy-3,5-dimethylaniline

2-(2-methoxy-3,5-dimethyl-phenoxy)-5-nitro-benzophenone

2,4-dimethyl-6-nitrophenol

4,6-dimethyl-2-nitroanisole

Downstream raw materials:

2-methoxy-3,5-dimethyl-2,5-cyclohexadiene-1,4-dione

3,5-dimethylcatechol

Refernces