2-Methoxy-3,5-dimethylaniline

Base Information

• Chemical Name: 2-Methoxy-3,5-dimethylaniline
• CAS No.: 35490-72-3
• Molecular Formula: C9H13 N O
• Molecular Weight: 151.208
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID90603605
• Wikidata: Q82501061
• Mol file: 35490-72-3.mol

Synonyms:2-Methoxy-3,5-dimethylaniline;35490-72-3;Benzenamine, 2-methoxy-3,5-dimethyl-;SCHEMBL359079;2-Methoxy-3,5-dimethylanilin;DTXSID90603605;AKOS005357294;SB76407;Benzenamine, 2-methoxy-3,5-dimethyl-;DB-086905;CS-0312155;EN300-114467;G53281;Z955139918

Chemical Property of 2-Methoxy-3,5-dimethylaniline

Chemical Property:

• PSA: 35.25000
• LogP: 2.47540
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 127

Purity/Quality:

99% ^*data from raw suppliers

2-methoxy-3,5-dimethylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)N)OC)C

Technology Process of 2-Methoxy-3,5-dimethylaniline

There total 5 articles about 2-Methoxy-3,5-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4,6-dimethyl-2-nitroanisole (69051-75-8) → 2-methoxy-3,5-dimethylaniline (35490-72-3)

Guidance literature:

With palladium on activated charcoal; In methanol; at 50 ℃; for 4h;

Reference yield: 55.0%

Benzoyl isothiocyanate (532-55-8) + Cresidine (120-71-8) → 2-methoxy-3,5-dimethylaniline (35490-72-3)

Guidance literature:

In acetonitrile; at 0 - 20 ℃; for 2h;

Reference yield:

2,4-dimethyl-6-nitrophenol (14452-34-7) → 2-methoxy-3,5-dimethylaniline (35490-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 2 h / 70 °C

2: stannous chloride, hydrochloric acid / ethanol

With hydrogenchloride; sodium hydroxide; tin(ll) chloride; In methanol; ethanol;

DOI:10.3891/acta.chem.scand.43-0044

upstream raw materials:

4,6-dimethyl-2-nitroanisole

2,4-dimethyl-6-nitrophenol

2,4-Xylenol

Benzoyl isothiocyanate

Downstream raw materials:

1-(2-Methoxy-3,5-dimethylphenyl)-thioharnstoff

6-Methylsulfon-2,4-dimethyl-anisol

6-Methylmercapto-2,4-dimethyl-anisol

3,5-dimethylcatechol