1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-(p-fluorophenyl)ribofuranuronamide

Base Information

Chemical Name:1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-(p-fluorophenyl)ribofuranuronamide
CAS No.:72758-44-2
Molecular Formula:C₁₆H₁₅FN₆O₄
Molecular Weight:374.331
Hs Code.:
Nikkaji Number:J342.252F
Wikidata:Q76155382

Synonyms:BRN 5658528;Adenosine-5'-(N-(p-fluorophenyl))carboxamide;1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-(p-fluorophenyl)ribofuranuronamide;Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-(p-fluorophenyl)-;72758-44-2;C16H15FN6O4;C16-H15-F-N6-O4;LS-143768;1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-(4-fluorophenyl)-beta-D-ribofuranuronamide

Suppliers and Price of 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-(p-fluorophenyl)ribofuranuronamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-(p-fluorophenyl)ribofuranuronamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.83g/cm³
XLogP3:0.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:3
Exact Mass:374.11388114
Heavy Atom Count:27
Complexity:551

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1NC(=O)C2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)O)F
Isomeric SMILES:C1=CC(=CC=C1NC(=O)[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)F

Technology Process of 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-(p-fluorophenyl)ribofuranuronamide

There total 3 articles about 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-(p-fluorophenyl)ribofuranuronamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3aS,4S,6R,6aR)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid (4-fluoro-phenyl)-amide

: 72758-44-2
(2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (4-fluoro-phenyl)-amide

Guidance literature:: With formic acid; at 70 ℃; for 5h;
DOI:10.1021/jm00177a021

Reference yield:

: 2146-07-8
p-fluoroaniline hydrochloride

: 72758-44-2
(2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (4-fluoro-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 15 h / Ambient temperature

2: 50percent aq. HCOOH / 5 h / 70 °C

With formic acid; triethylamine; In chloroform;
DOI:10.1021/jm00177a021

Reference yield:

: 39491-49-1
2',3'-O-isopropylideneadenosine-5'-carbonyl chloride

: 72758-44-2
(2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (4-fluoro-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 15 h / Ambient temperature

2: 50percent aq. HCOOH / 5 h / 70 °C

With formic acid; triethylamine; In chloroform;
DOI:10.1021/jm00177a021