2146-07-8

Basic information

• Product Name: 4-FLUOROANILINE HCL
• Synonyms: 4-FLUOROANILINE HCL;4-FLUOROANILINE HYDROCHLORIDE
• CAS NO: 2146-07-8
• Molecular Formula: C₆H₇FN*Cl
• Molecular Weight: 147.58
• Product Categories: Anilines, Amides & Amines;Fluorine Compounds
• Mol File: 2146-07-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: >200 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 167 °C/27 mmHg
• Appearance: /
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-FLUOROANILINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROANILINE HCL(2146-07-8)
• EPA Substance Registry System: 4-FLUOROANILINE HCL(2146-07-8)

Safety Data

• Hazardous Substances Data: 2146-07-8(Hazardous Substances Data)

Usage

General Description

4-Fluoroaniline HCL is a chemical compound that is commonly used in the pharmaceutical and dye industries. It is a derivative of aniline with a fluorine atom attached to the aromatic ring. The hydrochloride salt form of this compound is often used in research and development as a building block for the synthesis of various organic compounds. It is also used as an intermediate for the production of agrochemicals and other fine chemicals. However, it is important to handle this chemical with care as it can be toxic and hazardous if not properly managed.

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 3296-02-4 p-azidofluorobenzene 
• 351-83-7 4'-fluoroacetanilide 
• 925-90-6 ethylmagnesium bromide 
• 15873-72-0 dicyclohexylphosphinoyl chloride 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 103259-39-8 (4-Fluoro-phenyl)-(5,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-yl)-amine 
• 124573-72-4 2-(4-fluorophenyl)-2-((4-fluorophenyl)amino)acetonitrile 
• 88366-25-0 3-(4-Fluorophenyl)-3,7-dihydro-6-isobutyl-2,5-dimethyl-4H-pyrrolo<2,3-d>pyrimidin-4-imine 
• 65783-29-1 1-(4-fluorophenyl)-3-phenylguanidine 
• 459-05-2 (4-fluoro-phenyl)-thiourea 
• 1200835-75-1 1-((6-chloropyridin-3-yl)methyl)-5-(4-fluorophenyl)-1,3,5-hexahydrotriazine-2-(N-nitro)imine 
• 1325765-39-6 C₉H₁₀FN₅O₂ 
• 1200835-82-0 1-((2-chlorothiazol-5-yl)methyl)-5-(4-fluorophenyl)-1,3,5-hexahydrotriazine-2-(N-nitro)imine 
• 72358-71-5 4-<(4-fluorophenyl)amino>pyridine 
• 100633-90-7 (5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(4-fluoro-phenyl)-amine 
• 95927-66-5 6-Benzyl-N-(4-fluorophenyl)-2,5-dimethyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 95927-60-9 N-(4-Fluorophenyl)-2-methyl-5-phenyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 95927-63-2 N-(4-Fluorophenyl)-6-isobutyl-2,5-dimethyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 95927-56-3 N-(4-Fluorophenyl)-2,5-dimethyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 

Relevant articles and documents

Deoxygenation of Nitrous Oxide and Nitro Compounds Using Bis(N-Heterocyclic Silylene)Amido Iron Complexes as Catalysts

Herein, we report the efficient degradation of N2O with a well-defined bis(silylene)amido iron complex as catalyst. The deoxygenation of N2O using the iron silanone complex 4 as a catalyst and pinacolborane (HBpin) as a sacrificial reagent proceeds smoothly at 50 °C to form N2, H2, and (pinB)2O. Mechanistic studies suggest that the iron–silicon cooperativity is the key to this catalytic transformation, which involves N2O activation, H atom transfer, H2 release and oxygenation of the boron sites. This approach has been further developed to enable catalytic reductions of nitro compounds, producing amino-boranes with good functional-group tolerance and excellent chemoselectivity.

Mild N-deacylation of secondary amides by alkylation with organocerium reagents

Secondary amides are a class of highly stable compounds serving as versatile starting materials, intermediates and directing groups (amido groups) in organic synthesis. The direct deacylation of secondary amides to release amines is an important transformation in organic synthesis. Here, we report a protocol for the deacylation of secondary amides and isolation of amines. The method is based on the activation of amides with Tf2O, followed by addition of organocerium reagents, and acidic work-up. The reaction proceeded under mild conditions and afforded the corresponding amines, isolated as their hydrochloride salts, in good yields. In combination with the C-H activation functionalization methodology, the method is applicable to the functionalization of aniline as well as conversion of carboxylic derivatives to functionalized ketones.

Reduction of aromatic and aliphatic nitro groups to anilines and amines with hypophosphites associated with Pd/C

The reduction of aromatic and aliphatic nitro groups to anilines and amines is performed with good yield and selectivity in short reaction times. A mixture of sodium hypophosphite and phosphinic acid is used in the presence of a heterogeneous catalyst 2.5 mol% of Pd/C (5%) in a biphasic water/2-MeTHF system.