(HEPTAFLUOROBUTYRO)PHENONE

Base Information

• Chemical Name: (HEPTAFLUOROBUTYRO)PHENONE
• CAS No.: 559-91-1
• Molecular Formula: C10H5F7O
• Molecular Weight: 274.138
• Hs Code.: 2914700090
• Mol file: 559-91-1.mol

Synonyms:Heptafluoropropyl phenyl ketone;(Heptafluorobutyro)phenone;

Chemical Property of (HEPTAFLUOROBUTYRO)PHENONE

Chemical Property:

• Vapor Pressure: 0.705mmHg at 25°C
• Refractive Index: 1.4145
• Boiling Point: 185.2 °C at 760 mmHg
• Flash Point: 67.9 °C
• PSA: 17.07000
• Density: 1.425 g/cm³
• LogP: 3.70220

Purity/Quality:

99% ^*data from raw suppliers

HeptafluoropropylPhenylKetone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (HEPTAFLUOROBUTYRO)PHENONE

There total 11 articles about (HEPTAFLUOROBUTYRO)PHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl heptafluorobutyrate (356-27-4) + phenyllithium (591-51-5) → 1-phenylperfluorobutan-1-one (559-91-1)

Guidance literature:

With boron trifluoride diethyl etherate; In diethyl ether; at -78 ℃; for 1.5h;

DOI:10.1016/S0040-4020(01)80530-5

Reference yield: 65.0%

heptafluorobutyryl chloride (375-16-6) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 1-phenylperfluorobutan-1-one (559-91-1)

Guidance literature:

With SbF₅ intercalated in graphite; at 80 ℃; for 6h; autoclave;

Reference yield: 64.0%

Benzoyl bromide (618-32-6) + 2C3F7(1-)*Ag(1+)*Cu(1+) → 1-phenylperfluorobutan-1-one (559-91-1)

Guidance literature:

With propiononitrile; at 20 ℃; for 2h; Reagent/catalyst; Inert atmosphere;

DOI:10.1039/c5dt02925b

upstream raw materials:

heptafluorobutyronitrile

heptafluorobutyric Acid

diethyl ether

phenyllithium

Downstream raw materials:

4,4,5,5,6,6,6-heptafluoro-3-hydroxy-3-phenyl-hexanoic acid ethyl ester

(E)-5,5,6,6,7,7,7-heptafluoro-4-phenyl-3-hepten-2-one

(E)-5,5,6,6,7,7,7-heptafluoro-4-phenyl-3-hepten-2-ol

(E)-5,5,6,6,7,7,7-heptafluoro-4-phenyl-3-hepten-2-yl methanesulfonate

Refernces

• 1、 -. "Phosphate management with small molecules". Page/Page column 27. . Retrieved 2015/12/17.
• 2、 Konno, Tsutomu,Takehana, Tsuyoshi,Mishima, Makoto,Ishihara, Takashi. "Palladium-catalyzed regio- and stereoselective formate reduction of fluorine-containing allylic mesylates. A new entry for the construction of a tertiary carbon attached with a fluoroalkyl group". . p. 3545 - 3550. Retrieved 2007/10/03.