ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE

Base Information

• Chemical Name: ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE
• CAS No.: 126334-84-7
• Molecular Formula: C19H16ClNO2
• Molecular Weight: 325.795
• Hs Code.: 29339900
• Mol file: 126334-84-7.mol

Synonyms:Ethyl2-Chloromethyl-4-phenylquinoline-3-carboxylate;

Chemical Property of ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 5.63E-09mmHg at 25°C
• Refractive Index: 1.621
• Boiling Point: 469.2 °C at 760 mmHg
• Flash Point: 237.5 °C
• PSA: 39.19000
• Density: 1.233 g/cm³
• LogP: 5.61930

Purity/Quality:

≥95% ^*data from raw suppliers

2-Chloromethyl-4-phenyl-3-quinolinecarboxylicacidethylesterhydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE

There total 1 articles about ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl (2-chloroaceto)acetate (638-07-3) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → ethyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate (126334-84-7)

Guidance literature:

scandium tris(dodecyl sulfate); In water; at 40 ℃;

DOI:10.1002/adsc.200600527

Reference yield: 91.0%

ethyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate (126334-84-7) → 9-phenylfuro[3,4-b]quinoline-1(3H)-one (85422-43-1)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 216h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.12.061

Reference yield: 90.0%

ethyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate (126334-84-7) → 3-carbethoxy-2-(dichloromethyl)-4-phenylquinoline (129884-65-7)

Guidance literature:

With N-chloro-succinimide; Perbenzoic acid; In tetrachloromethane; for 72h; Heating;

upstream raw materials:

ethyl (2-chloroaceto)acetate

(2-aminophenyl)(phenyl)methanone

Downstream raw materials:

2,3-dihydro-9-phenyl-2-(2-pyridylmethyl)-1H-pyrrolo<3,4-b>quinolin-1-one

2,3-dihydro-9-phenyl-2-(4-pyridylmethyl)-1H-pyrrolo<3,4-b>quinolin-1-one

2,3-dihydro-2-(2-methylbenzyl)-9-phenyl-1H-pyrrolo<3,4-b>quinolin-1-one

2,3-dihydro-9-phenyl-2-(p-tolylamino)-1H-pyrrolo<3,4-b>quinolin-1-one

Refernces

• 1、 Zhang, Liang,Wu, Jie. "Friedlaender synthesis of quinolines using a lewis acid-surfactant- combined catalyst in water". . p. 1047 - 1051. Retrieved 2007.
• 2、 Blair, Adele,Stevenson, Louise,Dewar, Deborah,Pimlott, Sally L.,Sutherland, Andrew. "Structure-activity relationships of novel iodinated quinoline-2- carboxamides for targeting the translocator protein". supporting information. p. 1461 - 1466. Retrieved 2013/11/19.