6H-Pyrido(4,3-b)carbazole, 5-(hydroxymethyl)-11-methyl-

Base Information

• Chemical Name: 6H-Pyrido(4,3-b)carbazole, 5-(hydroxymethyl)-11-methyl-
• CAS No.: 108320-78-1
• Molecular Formula: C17H14 N2 O
• Molecular Weight: 262.311
• NSC Number: 610191
• DSSTox Substance ID: DTXSID80148499
• Nikkaji Number: J527.623C
• Wikidata: Q83014041
• ChEMBL ID: CHEMBL19570
• Mol file: 108320-78-1.mol

Synonyms:6H-Pyrido(4,3-b)carbazole, 5-(hydroxymethyl)-11-methyl-;6H-Pyrido(4,3-b)carbazole-5-methanol, 11-methyl-;5-(Hydroxymethyl)-11-methyl-6H-pyrido(4,3-b)carbazole;108320-78-1;NSC610191;CHEMBL19570;6H-Pyrido[4, 11-methyl-;SCHEMBL9678736;DTXSID80148499;NSC-610191;6H-Pyrido[4, 5-hydroxymethyl-11-methyl-;LS-133294;11-Methyl-6H-pyrido[4,3-b]carbazole-5-methanol;5-(Hydroxymethyl)-11-methyl-6H-pyrido [4,3-b] carbazole

Chemical Property of 6H-Pyrido(4,3-b)carbazole, 5-(hydroxymethyl)-11-methyl-

Chemical Property:

• Vapor Pressure: 1.56E-13mmHg at 25°C
• Boiling Point: 563.5°Cat760mmHg
• Flash Point: 294.6°C
• Density: 1.356g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 262.110613074
• Heavy Atom Count: 20
• Complexity: 361

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C=NC=CC2=C(C3=C1C4=CC=CC=C4N3)CO

Technology Process of 6H-Pyrido(4,3-b)carbazole, 5-(hydroxymethyl)-11-methyl-

There total 13 articles about 6H-Pyrido(4,3-b)carbazole, 5-(hydroxymethyl)-11-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

nitro-9 ellipticine (18073-35-3) → 5-(hydroxymethyl)-11-methyl-6H-pyrido<4,3-b>carbazole (108320-78-1)

Guidance literature:

Multistep reaction.;

DOI:10.1016/j.tetlet.2007.07.160

Reference yield: 26.0%

11-methyl-6H-pyrido<4,3-b>carbazole-5-carbaldehyde (77251-57-1) → 5-(hydroxymethyl)-11-methyl-6H-pyrido<4,3-b>carbazole (108320-78-1)

Guidance literature:

With hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; In methanol; for 120h; Ambient temperature; pH = 3;

Reference yield:

ellipticine (519-23-3) → 11-hydroxymethyl-5-methyl-6H-pyrido<4,3-b>carbazole (83329-79-7) + 5-(hydroxymethyl)-11-methyl-6H-pyrido<4,3-b>carbazole (108320-78-1) + 7-Hydroxyellipticine (67484-39-3) + ellipticine-N2-oxide (37687-33-5) + 9-hydroxyellipticine (51131-85-2)

Guidance literature:

With D-glucose 6-Phosphate Dehydrogenase; glucose-6-phosphate; cytochrome b5; human cytochrome P₄₅₀ 3A₄; NADP; In methanol; at 37 ℃; for 0.333333h; pH=7.4; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1021/tx3000335

upstream raw materials:

5-carbomethoxy-11-methyl-6H-pyrido<4,3-b>carbazole

11-methyl-6H-pyrido<4,3-b>carbazole-5-carbaldehyde

nitro-9 ellipticine

C₂₇H₃₂N₂O₄S

Downstream raw materials:

11-methyl-6H-pyrido<4,3-b>carbazole-5-carbaldehyde