77251-57-1Relevant academic research and scientific papers
L'OXO-17 ELIPTICINE, NOUVEL ALCALOIDE DE STRYCHNOS DINKLAGEI
Michel, S.,Tillequin, F.,Koch, M.
, p. 4027 - 4030 (1980)
The structure of 17-oxo ellipticine 1 has been established by spectral analysis and chemical correlation with ellipticine, and its biosynthesis and chemotaxonomic significance are discussed.
CHEMISTRY OF 6H-PYRIDOCARBAZOLES. PART 12. SYNTHESIS OF POTENTIAL BISINTERCALATING DRUGS BEARING TWO ELLIPTICINE UNITS
Ratcliffe, Andrew J.,Sainsbury, Malcolm,Smith, Andrew D.,Scopes, David I. C.
, p. 2933 - 2944 (2007/10/02)
A number of bisellipticines have been synthesized in an attempt to increase the potency of the parent tetracycles as anti-cancer drugs through bis-intercalation into the same strand of DNA.The compounds described are structures in which two pyridoc
Synthesis and Biological Properties of Some 6H-Pyridocarbazoles
Archer, Sidney,Ross, Bruce S.,Pica-Mattoccia, Livia,Cioli, Donato
, p. 1204 - 1210 (2007/10/02)
The effect of methyl substitution on the biological properties of the ellipticines was reexamined. 9-Hydroxy-6H-pyridocarbazole was synthesized and shown to be devoid of antitumor activity in murine P388 lymphocytic leukemia in mice. 5-(Hydroxymeth
SYNTHESIS OF 5-HYDROXYMETHYL-11-METHYL-6H-PYRIDOCARBAZOLE AND 5-FORMYL-11-METHYL-6H-PYRIDOcarbazole (17-OXOELLIPTICINE)
Ross, Bruce S.,Archer, Sydney
, p. 5343 - 5346 (2007/10/02)
A synthesis of 5-hydroxymethyl-11-methyl-6H-pyridocarbazole and the corresponding 5-formyl derivative, 17-oxoellipticine, is described, the key feature of which is the use of the Krohnke aldehyde synthesis to effect the debenzylation of a p-nitrobe
