5-Bromo-3-methoxy-2-nitropyridine

Base Information

• Chemical Name: 5-Bromo-3-methoxy-2-nitropyridine
• CAS No.: 152684-26-9
• Molecular Formula: C6H5BrN2O3
• Molecular Weight: 233.021
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30355858
• Wikidata: Q72446301
• Mol file: 152684-26-9.mol

Synonyms:5-bromo-3-methoxy-2-nitropyridine;152684-26-9;5-bromo-2-nitro-3-methoxypyridine;Pyridine, 5-bromo-3-methoxy-2-nitro-;MFCD00834963;SCHEMBL195009;DTXSID30355858;3-Bromo-5-methoxy-6-nitropyridine;CGA68426;CS-B1183;5-bromo-3-methoxy-2-nitro-pyridine;AKOS015891629;DS-15807;SY035901;FT-0652085;A809345;AC-907/34126018

Chemical Property of 5-Bromo-3-methoxy-2-nitropyridine

Chemical Property:

• Vapor Pressure: 0.000246mmHg at 25°C
• Melting Point: 112℃
• Refractive Index: 1.586
• Boiling Point: 334.6 °C at 760 mmHg
• PKA: -8.84±0.10(Predicted)
• Flash Point: 156.1 °C
• PSA: 67.94000
• Density: 1.73 g/cm³
• LogP: 2.28410
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 231.94835
• Heavy Atom Count: 12
• Complexity: 173

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-3-methoxy-2-nitropyridine 97% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(N=CC(=C1)Br)[N+](=O)[O-]

Technology Process of 5-Bromo-3-methoxy-2-nitropyridine

There total 2 articles about 5-Bromo-3-methoxy-2-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-bromo-5-methoxypyridine (50720-12-2) → 5-bromo-3-methoxy-2-nitropyridine (152684-26-9)

Guidance literature:

With sulfuric acid; nitric acid; In water; at 0 ℃; for 20h;

Reference yield:

3,5-dibromopyridine (625-92-3) → 5-bromo-3-methoxy-2-nitropyridine (152684-26-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / dimethylformamide / 2 h / 75 °C

2: 53 percent / H₂SO₄, HNO₃ / 1.5 h / 100 °C

With sulfuric acid; nitric acid; In N,N-dimethyl-formamide;

Reference yield: 99.0%

5-bromo-3-methoxy-2-nitropyridine (152684-26-9) → 5-bromo-3-methoxy-pyridin-2-amine (42409-58-5)

Guidance literature:

5-bromo-3-methoxy-2-nitropyridine; With iron; acetic acid; for 2.5h;

With sodium carbonate; In water; ethyl acetate;

upstream raw materials:

3-bromo-5-methoxypyridine

3,5-dibromopyridine

Downstream raw materials:

3-methoxy-5-(4-methylphenyl)-2-nitropyridine

3-methoxy-2-nitro-5-(3-nitrophenyl)pyridine

3-methoxy-2-nitro-5-phenylpyridine

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

Refernces

• 1、 -. "Quinolizinone compound and use thereof as HIV integrase inhibitor". Page/Page column 70. . Retrieved 2010/10/20.