1-Arabinofuranosyl-5-ethynylcytosine

Base Information

Chemical Name:1-Arabinofuranosyl-5-ethynylcytosine
CAS No.:74954-66-8
Molecular Formula:C₁₁H₁₃N₃O₅
Molecular Weight:267.241
Hs Code.:
DSSTox Substance ID:DTXSID20996456
Wikidata:Q82988248
Mol file:74954-66-8.mol

Synonyms:1-arabinofuranosyl-5-ethynylcytosine;5-EAC;5-ethynyl-1-beta-D-arabinofuranosylcytosine

Suppliers and Price of 1-Arabinofuranosyl-5-ethynylcytosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-Arabinofuranosyl-5-ethynylcytosine

Chemical Property:

Vapor Pressure:6.27E-13mmHg at 25°C
Boiling Point:518.7°C at 760 mmHg
Flash Point:267.5°C
PSA：107.20000
Density:1.67g/cm³
LogP:2.74840
XLogP3:-2.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:267.08552052
Heavy Atom Count:19
Complexity:506

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C#CC1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
Isomeric SMILES:C#CC1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O

Technology Process of 1-Arabinofuranosyl-5-ethynylcytosine

There total 4 articles about 1-Arabinofuranosyl-5-ethynylcytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110098-06-1
1-(2,3,5-tri-O-acetyl-β-D-arabinofuranosyl)-5-<2-(trimethylsilyl)ethynyl>cytosine

: 74954-66-8
EAC

: 110098-07-2
5-acetyl-1-β-D-arabinofuranosylcytosine

Guidance literature:: With potassium carbonate; In methanol; for 5h; Ambient temperature;
DOI:10.1021/jm00394a039

Reference yield:

: 58227-71-7
1-(2,3,5-tri-O-acetyl-β-D-arabinofuranosyl)cytosine hydrochloride

: 74954-66-8
EAC

Guidance literature:: Multi-step reaction with 3 steps

1: 80.2 percent / I₂, aq. HIO₃ / acetic acid; CCl₄ / 4 h / 40 °C

2: 83.4 percent / Et₃N, (PH₃P)2PdCl₂, CuI / 4 h / Ambient temperature

3: 64.6 percent / K₂CO₃ / methanol / 5 h / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; iodic acid; potassium carbonate; triethylamine; In methanol; tetrachloromethane; acetic acid;
DOI:10.1021/jm00394a039

Reference yield:

: 110098-05-0
1-(2,3,5-tri-O-acetyl-β-D-arabinofuranosyl)-5-iodocytosine

: 74954-66-8
EAC

Guidance literature:: Multi-step reaction with 2 steps

1: 83.4 percent / Et₃N, (PH₃P)2PdCl₂, CuI / 4 h / Ambient temperature

2: 64.6 percent / K₂CO₃ / methanol / 5 h / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In methanol;
DOI:10.1021/jm00394a039