4-phenyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:4-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:89160-45-2
Molecular Formula:C15H15 N
Molecular Weight:209.291
Hs Code.:2933499090
Mol file:89160-45-2.mol

Synonyms:Isoquinoline,1,2,3,4-tetrahydro-4-phenyl-, (R)-; (-)-4-Phenyltetrahydroisoquinoline

Suppliers and Price of 4-phenyl-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE 95.00%
5MG
$ 497.96

Total 3 raw suppliers

Chemical Property of 4-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Vapor Pressure:6.8E-05mmHg at 25°C
Boiling Point:344°C at 760 mmHg
Flash Point:171.2°C
PSA：12.03000
Density:1.065g/cm³
LogP:3.25050

Purity/Quality:: 4-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-phenyl-1,2,3,4-tetrahydroisoquinoline

There total 20 articles about 4-phenyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1408381-76-9
(4R)-4-phenyl-1,4-dihydroisoquinolin-3(2H)-one

: 89160-45-2
(4R)-(+)-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With diborane; In tetrahydrofuran; for 6h; Reflux;
DOI:10.1016/j.tetasy.2012.07.013

Reference yield: 35.0%

: (4R)-2-benzyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

: 89160-45-2
(4R)-(+)-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; at 20 ℃; for 3.16667h; Reflux;
DOI:10.1021/ol4013537

Reference yield:

: 197142-90-8
(S)-2-(N,N-dibenzylamino)-2-phenyl-1-ethanol

: 89160-45-2
(4R)-(+)-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: N-chloro-succinimide; triphenylphosphine / chloroform / 0 - 20 °C

2: aluminum (III) chloride / toluene / 0.17 h / 0 °C

3: ammonium formate; palladium 10% on activated carbon / methanol / 3.17 h / 20 °C / Reflux

With aluminum (III) chloride; N-chloro-succinimide; palladium 10% on activated carbon; ammonium formate; triphenylphosphine; In methanol; chloroform; toluene; 2: |Friedel-Crafts Alkylation;
DOI:10.1021/ol4013537