1408381-76-9

Upstream product

• 88393-58-2 (R)-N-benzyl-2-hydroxy-2-phenylacetamide 
• 1408381-65-6 (1R)-2-(benzylamino)-2-oxo-1-phenylethyl methanesulfonate 
• 1408381-69-0 (2R)-N-benzyl-2-chloro-2-phenylethanamide 
• 51019-43-3 (R)-(-)-O-acetylmandelic acid 
• 100-46-9 benzylamine 
• 81384-43-2 2-(benzylamino)-2-oxo-1-phenylethyl acetate 
• 4410-32-6 N-benzyl-2-hydroxy-2-phenylacetamide 

Downstream Products

• 89160-45-2 (4R)-(+)-4-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

A new chemoenzymatic approach to the synthesis of chiral 4-aryl-1,4-dihydro-2H-isoquinolines via the enzymatic resolution of 2-acetyl-4-phenyl-1,4-dihydro-2H-isoquinolin-3-one

A new chemoenzymatic method is proposed for the synthesis of enantiomerically pure 4-phenyl-1,4-dihydro-2H-isoquinolines based on the enzymatic kinetic resolution of 2-acetyl-4-phenyl-1,4-dihydro-2H-isoquinolin-3- one. For the enzymatic resolution of the racemic substrate, readily available 'home made' animal liver acetone powders (LAPs) were used. Excellent enantioselectivity, exceeding 500, was achieved in a short reaction time upon application of turkey liver acetone powder as the biocatalyst. Reduction of obtained product led to the formation of amine (R)-1, which is hardly available using standard procedures. These results show that N-acetyl lactams are a new type of substrate for enzymatic biotransformations.