Monilidiol

Base Information

• Chemical Name: Monilidiol
• CAS No.: 85414-34-2
• Molecular Formula: C₁₆H₂₁ClO₄
• Molecular Weight: 312.793
• Mol file: 85414-34-2.mol

Synonyms:

Chemical Property of Monilidiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Monilidiol

There total 21 articles about Monilidiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

monilidiol diacetate (88567-05-9) → monilidiol (85414-34-2)

Guidance literature:

With potassium carbonate;

DOI:10.1271/bbb1961.47.2411

Reference yield:

((4R,5S)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)methanol (88557-31-7) → monilidiol (85414-34-2)

Guidance literature:

Multi-step reaction with 9 steps

1: NaH

2: Amberlyst 15

4: H₂ / Pd/BaSO₄

5: 77.6 percent / oxidizing agent

6: 91 percent / n-butyllithium / diethyl ether

7: 74 percent / aq. AcOH

8: MnO₂

9: 84.6 percent / K₂CO₃

With manganese(IV) oxide; n-butyllithium; Amberlyst 15; oxidizing agent; hydrogen; sodium hydride; potassium carbonate; acetic acid; Pd-BaSO₄; In diethyl ether;

DOI:10.1271/bbb1961.47.2411

Reference yield:

(2R,3S)-octane-1,2,3-triol (88557-30-6) → monilidiol (85414-34-2)

Guidance literature:

Multi-step reaction with 12 steps

3: KOH

4: NaH

5: Amberlyst 15

7: H₂ / Pd/BaSO₄

8: 77.6 percent / oxidizing agent

9: 91 percent / n-butyllithium / diethyl ether

10: 74 percent / aq. AcOH

11: MnO₂

12: 84.6 percent / K₂CO₃

With manganese(IV) oxide; potassium hydroxide; n-butyllithium; Amberlyst 15; oxidizing agent; hydrogen; sodium hydride; potassium carbonate; acetic acid; Pd-BaSO₄; In diethyl ether;

DOI:10.1271/bbb1961.47.2411

upstream raw materials:

monilidiol diacetate

2,3-Dimethylphenol

((4R,5S)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)methanol

(2R,3S)-octane-1,2,3-triol

Downstream raw materials:

C₂₂H₂₄O₅

hexanal

C₂₂H₂₆O₅