monilidiol diacetate

Base Information

• Chemical Name: monilidiol diacetate
• CAS No.: 88567-05-9
• Molecular Formula: C₂₀H₂₅ClO₆
• Molecular Weight: 396.868
• Mol file: 88567-05-9.mol

Synonyms:

Chemical Property of monilidiol diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of monilidiol diacetate

There total 20 articles about monilidiol diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((4R,5S)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)methanol (88557-31-7) → monilidiol diacetate (88567-05-9)

Guidance literature:

Multi-step reaction with 8 steps

1: NaH

2: Amberlyst 15

4: H₂ / Pd/BaSO₄

5: 77.6 percent / oxidizing agent

6: 91 percent / n-butyllithium / diethyl ether

7: 74 percent / aq. AcOH

8: MnO₂

With manganese(IV) oxide; n-butyllithium; Amberlyst 15; oxidizing agent; hydrogen; sodium hydride; acetic acid; Pd-BaSO₄; In diethyl ether;

DOI:10.1271/bbb1961.47.2411

Reference yield:

(2R,3S)-octane-1,2,3-triol (88557-30-6) → monilidiol diacetate (88567-05-9)

Guidance literature:

Multi-step reaction with 11 steps

3: KOH

4: NaH

5: Amberlyst 15

7: H₂ / Pd/BaSO₄

8: 77.6 percent / oxidizing agent

9: 91 percent / n-butyllithium / diethyl ether

10: 74 percent / aq. AcOH

11: MnO₂

With manganese(IV) oxide; potassium hydroxide; n-butyllithium; Amberlyst 15; oxidizing agent; hydrogen; sodium hydride; acetic acid; Pd-BaSO₄; In diethyl ether;

DOI:10.1271/bbb1961.47.2411

Reference yield:

2,2-Dimethyl-propionic acid (2R,3S)-2,3-dihydroxy-octyl ester (106031-55-4) → monilidiol diacetate (88567-05-9)

Guidance literature:

Multi-step reaction with 10 steps

2: KOH

3: NaH

4: Amberlyst 15

6: H₂ / Pd/BaSO₄

7: 77.6 percent / oxidizing agent

8: 91 percent / n-butyllithium / diethyl ether

9: 74 percent / aq. AcOH

10: MnO₂

With manganese(IV) oxide; potassium hydroxide; n-butyllithium; Amberlyst 15; oxidizing agent; hydrogen; sodium hydride; acetic acid; Pd-BaSO₄; In diethyl ether;

DOI:10.1271/bbb1961.47.2411

upstream raw materials:

Acetic acid (1R,2S)-2-acetoxy-1-[(E)-2-(4-chloro-3-hydroxy-2-hydroxymethyl-phenyl)-vinyl]-heptyl ester

2,3-Dimethylphenol

((4R,5S)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)methanol

(2R,3S)-octane-1,2,3-triol

Downstream raw materials:

monilidiol