Diclofensine

Base Information

Chemical Name:Diclofensine
CAS No.:67165-56-4
Molecular Formula:C17H17Cl2NO
Molecular Weight:322.234
Hs Code.:2933499090
UNII:09HKW863J6
DSSTox Substance ID:DTXSID30867264
Nikkaji Number:J1.874.218G
Wikipedia:Diclofensine
Wikidata:Q5273862
NCI Thesaurus Code:C78017
ChEMBL ID:CHEMBL287257

Synonyms:diclofensine;diclofensine hydrochloride;Ro 8-4650

Suppliers and Price of Diclofensine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 95+%
250mg
$ 1701.00

DC Chemicals
Diclofensine(Ro8-4650) >99%
250 mg
$ 500.00

DC Chemicals
Diclofensine(Ro8-4650) >99%
100 mg
$ 250.00

Crysdot
Diclofensine 98+%
10mg
$ 64.00

Crysdot
Diclofensine 98+%
50mg
$ 273.00

Chemenu
4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 98%
50mg
$ 255.00

Biosynth Carbosynth
Diclofensine
50 mg
$ 450.00

Biosynth Carbosynth
Diclofensine
25 mg
$ 300.00

Biosynth Carbosynth
Diclofensine
10 mg
$ 180.00

Biosynth Carbosynth
Diclofensine
5 mg
$ 120.00

Total 84 raw suppliers

Chemical Property of Diclofensine

Chemical Property:

Vapor Pressure:2.38E-07mmHg at 25°C
Refractive Index:1.59
Boiling Point:422.595 °C at 760 mmHg
PKA:7.87±0.40(Predicted)
Flash Point:209.378 °C
PSA：12.47000
Density:1.242 g/cm³
LogP:4.51720
XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:321.0687196
Heavy Atom Count:21
Complexity:354

Purity/Quality:

99%, ^*data from raw suppliers

4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CC(C2=C(C1)C=C(C=C2)OC)C3=CC(=C(C=C3)Cl)Cl
Uses A stimulant; inhibits reuptake of dopamine and noradrenaline, is an effective antidepressant. Compound exhibits significant addictive properties.

Technology Process of Diclofensine

There total 5 articles about Diclofensine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 802051-24-7
1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol

: 692248-97-8
4-(3,4-dichlorophenyl)-5-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 67165-56-4
Diclofensine

Guidance literature:: 1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol; With sulfuric acid; In dichloromethane; at 0 ℃; for 28h;

With sodium hydroxide; In dichloromethane; pH=9;

Reference yield:

: 1254941-88-2
1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanone

: 67165-56-4
Diclofensine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

2.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C

2.2: pH ~ 9

With sodium tetrahydroborate; sulfuric acid; In methanol; dichloromethane; water;

Reference yield:

: 41789-95-1
1-(3-methoxyphenyl)-N-methylmethanamine

: 67165-56-4
Diclofensine

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

3.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C

3.2: pH ~ 9

With sodium tetrahydroborate; sulfuric acid; In methanol; dichloromethane; water;