4-Aminobicyclo[2.2.2]octane-1-carboxylic acid

Base Information

Chemical Name:4-Aminobicyclo[2.2.2]octane-1-carboxylic acid
CAS No.:13595-17-0
Molecular Formula:C9H15 N O2
Molecular Weight:169.224
Hs Code.:2922499990
DSSTox Substance ID:DTXSID80159601
Nikkaji Number:J1.740.596I
Mol file:13595-17-0.mol

Synonyms:4-aminobicyclo(2,2,2)octane-1-carboxylic acid

Suppliers and Price of 4-Aminobicyclo[2.2.2]octane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-Aminobicyclo[2.2.2]octane-1-carboxylic acid
5g
$ 1710.00

Matrix Scientific
4-Aminobicyclo[2.2.2]octane-1-carboxylic acid
1g
$ 720.00

Crysdot
4-Aminobicyclo[2.2.2]octane-1-carboxylicacid 95+%
1g
$ 646.00

Crysdot
4-Aminobicyclo[2.2.2]octane-1-carboxylicacid 95+%
250mg
$ 258.00

Chemenu
4-Aminobicyclo[2.2.2]octane-1-carboxylicacid 95%
1g
$ 837.00

American Custom Chemicals Corporation
4-AMINOBICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID 95.00%
5MG
$ 500.10

Absolute Chiral
4-aminobicyclo[2.2.2]octane-1-carboxylicacid 95%
250 mg
$ 318.00

Absolute Chiral
4-aminobicyclo[2.2.2]octane-1-carboxylicacid 95%
100 mg
$ 158.00

A1 Biochem Labs
4-Aminobicyclo[2.2.2]octane-1-carboxylicacid 95%
2.5 g
$ 1000.00

A1 Biochem Labs
4-Aminobicyclo[2.2.2]octane-1-carboxylicacid 95%
1 g
$ 550.00

Total 15 raw suppliers

Chemical Property of 4-Aminobicyclo[2.2.2]octane-1-carboxylic acid

Chemical Property:

Vapor Pressure:0.000304mmHg at 25°C
Boiling Point:298.3°Cat760mmHg
PKA:4.52±0.10(Predicted)
Flash Point:134.2°C
PSA：63.32000
Density:1.279g/cm³
LogP:1.82300
Storage Temp.:2-8°C(protect from light)
XLogP3:-2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:169.110278721
Heavy Atom Count:12
Complexity:200

Purity/Quality:

98+% ^*data from raw suppliers

4-Aminobicyclo[2.2.2]octane-1-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC2(CCC1(CC2)C(=O)O)N
Uses 4-Aminobicyclo[2.2.2]octane-1-carboxylic Acid can be used in the preparation of AA-115/APG-115, potent and orally active murine double minute 2 inhibitor useful in cancer treatment. It can be useful in structure activity optimization of 6H-?pyrrolo[2,?3-?e]?[1,?2,?4]?triazolo[4,?3-?a]?pyrazines as Jak1 kinase inhibitors. It may also be useful in the preparation of PI3Kγ inhibitors.

Technology Process of 4-Aminobicyclo[2.2.2]octane-1-carboxylic acid

There total 8 articles about 4-Aminobicyclo[2.2.2]octane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 834-50-4
4-(ethoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid

: 13595-17-0
4-amino-bicyclo[2.2.2]octane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; chlorocarbonic acid ethyl ester; NH₃

2: ethanolic sodium ethylate; bromine

3: aqueous HCl

With hydrogenchloride; ammonia; bromine; sodium ethanolate; chloroformic acid ethyl ester; triethylamine;
DOI:10.3758/BF03211828