Bicyclo[2.2.2]octane-1-carboxylic acid, 4-aMino-, ethyl ester

Base Information

• Chemical Name: Bicyclo[2.2.2]octane-1-carboxylic acid, 4-aMino-, ethyl ester
• CAS No.: 135908-45-1
• Molecular Formula: C₁₁H₁₉NO₂
• Molecular Weight: 197.277
• Hs Code.: 2922498590
• Mol file: 135908-45-1.mol

Synonyms:Bicyclo[2.2.2]octane-1-carboxylic acid, 4-aMino-, ethyl ester;4-amino-Bicyclo[2.2.2]octane-1-carboxylic acid ethyl ester;Ethyl4-aminobicyclo[2.2.2]octane-1-carboxylate

Chemical Property of Bicyclo[2.2.2]octane-1-carboxylic acid, 4-aMino-, ethyl ester

Chemical Property:

• PSA: 52.32000
• LogP: 2.30150

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Bicyclo[2.2.2]octane-1-carboxylic acid, 4-aMino-, ethyl ester

There total 12 articles about Bicyclo[2.2.2]octane-1-carboxylic acid, 4-aMino-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 4-(benzylamino)bicyclo[2.2.2]oct-2-ene-1-carboxylate (1207166-79-7) → ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (135908-45-1)

Guidance literature:

With hydrogen; palladium on carbon; In ethanol; toluene; at 20 ℃; for 7h;

Reference yield:

ethyl 4-[[(benzyloxy)carbonyl]amino]-bicyclo[2.2.2]octane-1-carboxylate (444344-90-5) → ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (135908-45-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 6h;

Reference yield:

ethanol (64-17-5) + 4-amino-bicyclo[2.2.2]octane-1-carboxylic acid (13595-17-0) → ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (135908-45-1)

Guidance literature:

With thionyl chloride; at 0 ℃; for 3h; Inert atmosphere; Reflux;

upstream raw materials:

ethyl 4-[[(benzyloxy)carbonyl]amino]-bicyclo[2.2.2]octane-1-carboxylate

ethyl 1-acetyl-4-oxocyclohexane-1-carboxylate

ethyl 4-(benzylamino)-2-oxobicyclo[2.2.2]octane-1-carboxylate

ethyl 4-(benzylamino)-2-hydroxybicyclo[2.2.2]octane-1-carboxylate

Downstream raw materials:

(4-aminobicyclo[2.2.2]octan-1-yl)methanol

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