1-(1-Methyl-2,2-diphenylcyclopropyl)ethanone

Base Information

• Chemical Name: 1-(1-Methyl-2,2-diphenylcyclopropyl)ethanone
• CAS No.: 27067-38-5
• Molecular Formula: C₁₈H₁₈O
• Molecular Weight: 250.34
• NSC Number: 120438
• DSSTox Substance ID: DTXSID60298062
• Mol file: 27067-38-5.mol

Synonyms:27067-38-5;1-(1-methyl-2,2-diphenylcyclopropyl)ethanone;NSC120438;DTXSID60298062;NSC-120438

Chemical Property of 1-(1-Methyl-2,2-diphenylcyclopropyl)ethanone

Chemical Property:

• Vapor Pressure: 2.29E-05mmHg at 25°C
• Boiling Point: 360°Cat760mmHg
• Flash Point: 153.8°C
• Density: 1.089g/cm³
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 250.135765193
• Heavy Atom Count: 19
• Complexity: 329

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1(CC1(C2=CC=CC=C2)C3=CC=CC=C3)C

Technology Process of 1-(1-Methyl-2,2-diphenylcyclopropyl)ethanone

There total 4 articles about 1-(1-Methyl-2,2-diphenylcyclopropyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-2,2-diphenylcyclopropanecarboxylic acid (35389-12-9,27067-47-6) + methyllithium (917-54-4) → rac-1-Methyl-1-acetyl-2,2-diphenyl-cyclopropan (27067-38-5)

Guidance literature:

DOI:10.1021/ja00883a041

Reference yield:

cyclopropane, 1,1-diphenyl-2-methyl-2-<2-(methylthio)-1-(methyl)ethenyl>- (28562-37-0) → rac-1-Methyl-1-acetyl-2,2-diphenyl-cyclopropan (27067-38-5)

Guidance literature:

Multistep reaction; (i) O₃, CH₂Cl₂, MeOH, (ii) Zn, AcOH;

DOI:10.1016/0040-4020(76)85177-0

Reference yield:

3,6-Dihydro-4,5-dimethyl-2,2-diphenyl-2H-thiopyran (40754-58-3) → rac-1-Methyl-1-acetyl-2,2-diphenyl-cyclopropan (27067-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) nBuLi, DABCO, THF, (ii) /BRN= 3587162/

2: (i) O₃, CH₂Cl₂, MeOH, (ii) Zn, AcOH

DOI:10.1016/0040-4020(76)85177-0

upstream raw materials:

cyclopropane, 1,1-diphenyl-2-methyl-2-<2-(methylthio)-1-(methyl)ethenyl>-

1-methyl-2,2-diphenylcyclopropanecarboxylic acid

methyllithium

3,6-Dihydro-4,5-dimethyl-2,2-diphenyl-2H-thiopyran