(2R,3R)-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1,2,4-triazol-1-yl)butan-2-ol

Base Information

• Chemical Name: (2R,3R)-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1,2,4-triazol-1-yl)butan-2-ol
• CAS No.: 134779-41-2
• Molecular Formula: C₁₃H₁₅F₂N₃O₃S
• Molecular Weight: 331.343
• Mol file: 134779-41-2.mol

Synonyms:1H-1,2,4-Triazole-1-ethanol,a-(2,4-difluorophenyl)-a-[1-(methylsulfonyl)ethyl]-,[S-(R*,R*)]-; (S,S)-SCH 39304; Sch 42426

Chemical Property of (2R,3R)-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1,2,4-triazol-1-yl)butan-2-ol

Chemical Property:

• Vapor Pressure: 5.73E-15mmHg at 25°C
• Boiling Point: 594.3°Cat760mmHg
• Flash Point: 313.2°C
• PSA: 93.46000
• Density: 1.42g/cm³
• LogP: 1.95800

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,3R)-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1,2,4-triazol-1-yl)butan-2-ol

There total 47 articles about (2R,3R)-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1,2,4-triazol-1-yl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol (182699-19-0) → (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methanesulfonyl-1-[1,2,4]triazol-1-yl-butan-2-ol (182699-15-6,134779-41-2)

Guidance literature:

With hydrogenchloride; sodium tungstate; dihydrogen peroxide; In toluene; at 60 ℃; for 1h;

DOI:10.1246/bcsj.69.2625

Reference yield: 92.0%

(2R,3R)-2-(2,4-difluorophenyl)-3-(methylthio)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (133775-27-6) → (2R,3R)-2-(2,4-difluorophenyl)-3-(methylsulfonyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (134779-41-2)

Guidance literature:

With hydrogenchloride; sodium tungstate; dihydrogen peroxide; In water; at 40 ℃; for 2h;

DOI:10.1246/bcsj.68.3591

Reference yield: 90.0%

threo-2-(2,4-difluorophenyl)-3-methylthio-1-(1H-1,2,4-triazol-1-yl)-2-butanol → threo-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol (134779-41-2)

Guidance literature:

With hydrogenchloride; sodium tungstate; dihydrogen peroxide; In methanol; at 60 ℃; for 3h;

DOI:10.1246/bcsj.67.1427

upstream raw materials:

(2R^*,3S^*)-2-(2,4-Difluorophenyl)-3-methyl-2-<(1H-1,2,4-triazol-1-yl)methyl>oxirane

threo-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol

(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol

(2R,3R)-2-(2,4-difluorophenyl)-3-(methylthio)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol