(2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol

Base Information

• Chemical Name: (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol
• CAS No.: 182699-19-0
• Molecular Formula: C₁₃H₁₅F₂N₃OS
• Molecular Weight: 299.344
• Mol file: 182699-19-0.mol

Synonyms:(2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol

Chemical Property of (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol

There total 8 articles about (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole (135270-13-2) + sodium thiomethoxide (5188-07-8) → (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol (182699-19-0)

Guidance literature:

In water; dimethyl sulfoxide; at 55 ℃; for 3h;

DOI:10.1246/bcsj.69.2625

Reference yield: 72.0%

1,2,4-Triazole (288-88-0) + (S)-2-(2,4-Difluoro-phenyl)-2-((S)-1-methylsulfanyl-ethyl)-oxirane (147383-77-5) → (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol (182699-19-0)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 3h;

DOI:10.1246/bcsj.69.2625

Reference yield:

(E)-2-(2,4-difluorophenyl)-2-buten-1-ol (173787-23-0) → (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol (182699-19-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / Ti(O-iPr)4, t-butyl hydroperoxide, (-)-diethyl (2S,3S)-tartrate / CH₂Cl₂ / 48 h / -20 °C

2: 77 percent / dimethylsulfoxide; H₂O / 3 h / 55 °C

3: Et₃N / toluene / 0.5 h / 0 °C

4: 15percent aq. KOH / toluene / 2 h / 0 °C

5: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; potassium hydroxide; sodium hydroxide; diethyl (2S,3S)-tartrate; triethylamine; In dichloromethane; water; dimethyl sulfoxide; toluene;

DOI:10.1246/bcsj.69.2625

upstream raw materials:

1,2,4-Triazole

(S)-2-(2,4-Difluoro-phenyl)-2-((S)-1-methylsulfanyl-ethyl)-oxirane

1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

sodium thiomethoxide

Downstream raw materials:

(2R,3S)-2-(2,4-Difluoro-phenyl)-3-methanesulfonyl-1-[1,2,4]triazol-1-yl-butan-2-ol

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

(2R,3R)-2-(2,4-difluorophenyl)-3-(methylsulfonyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol