5,6-Dihydroxyprostaglandin F1a

Base Information

Chemical Name:5,6-Dihydroxyprostaglandin F1a
CAS No.:87692-41-9
Molecular Formula:C₂₀H₃₆O₇
Molecular Weight:388.502
Hs Code.:
Metabolomics Workbench ID:41834
Mol file:87692-41-9.mol

Synonyms:5,6-DH-PGF1;5,6-dihydroxyprostaglandin F1

Suppliers and Price of 5,6-Dihydroxyprostaglandin F1a

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5,6-Dihydroxyprostaglandin F1a

Chemical Property:

Vapor Pressure:2.03E-17mmHg at 25°C
Boiling Point:609.8°C at 760 mmHg
Flash Point:336.6°C
PSA：138.45000
Density:1.255g/cm³
LogP:1.20850
XLogP3:1
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:13
Exact Mass:388.24610348
Heavy Atom Count:27
Complexity:454

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC1C(CC(C1CC(C(CCCC(=O)O)O)O)O)O)O
Isomeric SMILES:CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1CC(C(CCCC(=O)O)O)O)O)O)O

Technology Process of 5,6-Dihydroxyprostaglandin F1a

There total 8 articles about 5,6-Dihydroxyprostaglandin F1a which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13345-50-1
prostaglandin A₂

: 87692-41-9
5,6-dihydro-5,6-dihydroxy-PGF_2α

Guidance literature:: Multi-step reaction with 8 steps

1: diethyl ether / 0.5 h / 0 - 5 °C

2: imidazole / dimethylformamide / 2 h / Ambient temperature

3: 95 percent / 30percent hydrogen peroxide, 3 M aq. lithium hydroxide / methanol / 5 h / -30 - -25 °C

4: aq. sodium hydrogen carbonate, aluminium amalgam / tetrahydrofuran; methanol / 1.) 10 deg C, 2 h, 2.) room temperature, 4 h

5: 80 percent / K-Selectride / tetrahydrofuran / 5 h / -50 - -45 °C

6: 65 percent / N-methylmorpholine N-oxide dihydrate, water, osmium tetraoxide / 2-methyl-propan-2-ol; acetone / 0.67 h

7: 3 M lithium hydroxide / methanol / 2 h / Ambient temperature

8: 46 mg / hydrofluoric acid / acetonitrile / 1.5 h

With 1H-imidazole; lithium hydroxide; osmium(VIII) oxide; aluminium amalgam; hydrogen fluoride; water; dihydrogen peroxide; sodium hydrogencarbonate; potassium tri-sec-butyl-borohydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol;

Reference yield:

: 31753-19-2
(5Z,13E)-15-hydroxy-9-oxoprosta 5,10,13 trien-1-oic acid

: 87692-41-9
5,6-dihydro-5,6-dihydroxy-PGF_2α

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole / dimethylformamide / 2 h / Ambient temperature

2: 95 percent / 30percent hydrogen peroxide, 3 M aq. lithium hydroxide / methanol / 5 h / -30 - -25 °C

3: aq. sodium hydrogen carbonate, aluminium amalgam / tetrahydrofuran; methanol / 1.) 10 deg C, 2 h, 2.) room temperature, 4 h

4: 80 percent / K-Selectride / tetrahydrofuran / 5 h / -50 - -45 °C

5: 65 percent / N-methylmorpholine N-oxide dihydrate, water, osmium tetraoxide / 2-methyl-propan-2-ol; acetone / 0.67 h

6: 3 M lithium hydroxide / methanol / 2 h / Ambient temperature

7: 46 mg / hydrofluoric acid / acetonitrile / 1.5 h

With 1H-imidazole; lithium hydroxide; osmium(VIII) oxide; aluminium amalgam; hydrogen fluoride; water; dihydrogen peroxide; sodium hydrogencarbonate; potassium tri-sec-butyl-borohydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol;

Reference yield:

: 53122-04-6
15α-O-t-butyldimethylsilyl-PGA₂ methyl ester

: 87692-41-9
5,6-dihydro-5,6-dihydroxy-PGF_2α

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / 30percent hydrogen peroxide, 3 M aq. lithium hydroxide / methanol / 5 h / -30 - -25 °C

2: aq. sodium hydrogen carbonate, aluminium amalgam / tetrahydrofuran; methanol / 1.) 10 deg C, 2 h, 2.) room temperature, 4 h

3: 80 percent / K-Selectride / tetrahydrofuran / 5 h / -50 - -45 °C

4: 65 percent / N-methylmorpholine N-oxide dihydrate, water, osmium tetraoxide / 2-methyl-propan-2-ol; acetone / 0.67 h

5: 3 M lithium hydroxide / methanol / 2 h / Ambient temperature

6: 46 mg / hydrofluoric acid / acetonitrile / 1.5 h

With lithium hydroxide; osmium(VIII) oxide; aluminium amalgam; hydrogen fluoride; water; dihydrogen peroxide; sodium hydrogencarbonate; potassium tri-sec-butyl-borohydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; acetone; acetonitrile; tert-butyl alcohol;