4-(4-Methoxynaphthalen-1-yl)butanoic acid

Base Information

• Chemical Name: 4-(4-Methoxynaphthalen-1-yl)butanoic acid
• CAS No.: 10465-20-0
• Molecular Formula: C15H16 O3
• Molecular Weight: 244.2857
• NSC Number: 97645
• DSSTox Substance ID: DTXSID80294687
• Wikidata: Q82034092
• Mol file: 10465-20-0.mol

Synonyms:4-(4-methoxynaphthalen-1-yl)butanoic acid;10465-20-0;NSC97645;1-Naphthalenebutanoicacid, 4-methoxy-;4-(4-methoxy-1-naphthyl)butanoic acid;Oprea1_332652;SCHEMBL15802462;DTXSID80294687;NSC-97645;4-(4-methoxy-naphthalen-1-yl)-butyric acid;CS-0440180;EN300-1856516;AG-207/31086015

Chemical Property of 4-(4-Methoxynaphthalen-1-yl)butanoic acid

Chemical Property:

• Vapor Pressure: 3.03E-08mmHg at 25°C
• Boiling Point: 432.4°Cat760mmHg
• Flash Point: 163.3°C
• Density: 1.174g/cm³
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 244.109944368
• Heavy Atom Count: 18
• Complexity: 277

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C2=CC=CC=C21)CCCC(=O)O

Technology Process of 4-(4-Methoxynaphthalen-1-yl)butanoic acid

There total 10 articles about 4-(4-Methoxynaphthalen-1-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid (3562-99-0) → γ-(4-methoxy-1-naphthyl)butyric acid (10465-20-0)

Guidance literature:

With hydrogenchloride; amalgamated zinc; acetic acid; weiteres Reagens: Toluol; Behandeln des Reaktionsprodukts mit wss. Natronlauge und Dimethylsulfat;

DOI:10.1007/BF02959450 DOI:10.1021/ja01867a041

Reference yield:

1-Methoxynaphthalene (2216-69-5) → γ-(4-methoxy-1-naphthyl)butyric acid (10465-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: nitrobenzene; aluminium chloride

2: amalgamated zinc; aqueous hydrochloric acid; acetic acid / weiteres Reagens: Toluol; Behandeln des Reaktionsprodukts mit wss. Natronlauge und Dimethylsulfat

With hydrogenchloride; aluminium trichloride; amalgamated zinc; acetic acid; nitrobenzene;

DOI:10.1007/BF02959450 DOI:10.1021/ja01867a041

Reference yield:

5,6,7,8-Tetrahydronaphthalen-1-ol (529-35-1) → γ-(4-methoxy-1-naphthyl)butyric acid (10465-20-0)

Guidance literature:

Multi-step reaction with 4 steps

1: aqueous NaOH

2: aluminium chloride; nitrobenzene

3: amalgamated zinc; aqueous hydrochloric acid; acetic acid / weiteres Reagens: Toluol

4: Erhitzen des Methylesters mit Palladium/Kohle auf 250grad bis 280grad und anschliessend Hydrolysieren

With hydrogenchloride; sodium hydroxide; aluminium trichloride; amalgamated zinc; acetic acid; nitrobenzene;

DOI:10.1021/ja01255a018

upstream raw materials:

diazomethane

γ-(4-methoxy-5,6,7,8-tetrahydro-1-naphthyl)butyric acid

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

[2-(4-methoxy-[1]naphthyl)-ethyl]-malonic acid

Downstream raw materials:

(S)-4-benzyl-3-(4-(4-methoxynaphthalen-1-yl)butanoyl)oxazolidin-2-one

3H-1-carbethoxy-10,11-dihydro-5-methoxy-3-phenylphenanthro<1,2-c>pyrazole

3H-10,11-dihydro-5-methoxy-3-phenylphenanthro<1,2-c>pyrazole

C₃₇H₄₄N₄O₅

Refernces

• 1、 -. "3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS". Paragraph 0318. . Retrieved 2014/06/25.
• 2、 Coombs,Jaitly,Crawley. "Potentially carcinogenic cyclopenta[a]phenanthrenes. IV. Synthesis of 17-ketones by the Stobbe condensation.". . p. 1266 - 1271. Retrieved 2007/10/06.