1-Methoxynaphthalene

Base Information

• Chemical Name: 1-Methoxynaphthalene
• CAS No.: 2216-69-5
• Molecular Formula: C11H10O
• Molecular Weight: 158.2
• Hs Code.: 29093090
• European Community (EC) Number: 218-696-1
• NSC Number: 5530
• UNII: DG2EOL57LF
• DSSTox Substance ID: DTXSID5062263
• Nikkaji Number: J7.365B
• Wikidata: Q27276378
• Mol file: 2216-69-5.mol

Synonyms:1-methoxynaphthalene

Chemical Property of 1-Methoxynaphthalene

Chemical Property:

• Appearance/Colour: clear light yellow to brown liquid
• Vapor Pressure: 0.0128mmHg at 25°C
• Melting Point: 5 °C
• Refractive Index: n20/D 1.621(lit.)
• Boiling Point: 268.3 °C at 760 mmHg
• Flash Point: 102.3 °C
• PSA: 9.23000
• Density: 1.072 g/cm³
• LogP: 2.84840
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform, Methanol
• Water Solubility.: immiscible
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 158.073164938
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

99.9% ^*data from raw suppliers

1-Methoxynaphthalene ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=CC2=CC=CC=C21
• Uses: 1-Methoxynaphthalene is used in the study of peroxygenase activity of cytochrome c peroxidase. It is used as a precursor to synthesize prenyl naphthalene-ols, which shows antioxidative activity. It is also used in organic synthesis, pesticides, perfumes for making soaps, and film developers.

Technology Process of 1-Methoxynaphthalene

There total 104 articles about 1-Methoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-bromonaphthalene (580-13-2) + sodium methylate (124-41-4) → 2-Methoxynaphthalene (93-04-9) + 1-Methoxynaphthalene (2216-69-5)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; at 120 ℃; for 2h;

DOI:10.1016/S0040-4020(01)97647-1

Reference yield: 68.0%

1-Bromonaphthalene (90-11-9) + sodium methylate (124-41-4) → 2-Methoxynaphthalene (93-04-9) + 1-Methoxynaphthalene (2216-69-5)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; at 120 ℃; for 2h;

DOI:10.1016/S0040-4020(01)97647-1

Reference yield: 40.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 1-<<(4-methoxyphenyl)sulfonyl>oxy>naphthalene (123412-33-9) → α-naphthol (90-15-3) + methyl 1-naphthoate (2459-24-7) + 1-Methoxynaphthalene (2216-69-5)

Guidance literature:

With sodium tetracarbonyl cobaltate; potassium carbonate; dimethyl sulfate; In methanol; at 45 ℃; Product distribution; other naphthyl mono- and di-sulfonates;

DOI:10.1016/0022-328X(93)83037-V

upstream raw materials:

methanol

α-naphthol

sodium naphtholate

2-(4-methoxy-1-naphthoyl)benzoic acid

Downstream raw materials:

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

1-chloro-4-methoxynaphthalene

2-(4-methoxy-1-naphthoyl)benzoic acid

α-naphthol