Hexanedioic acid, 2-(diethoxyphosphinyl)-, diethyl ester

Base Information

Chemical Name:Hexanedioic acid, 2-(diethoxyphosphinyl)-, diethyl ester
CAS No.:66827-11-0
Molecular Formula:C14H27O7P
Molecular Weight:338.3337
Hs Code.:
NSC Number:133827
DSSTox Substance ID:DTXSID50299947
Nikkaji Number:J1.409.924G

Synonyms:Hexanedioic acid, 2-(diethoxyphosphinyl)-, diethyl ester;66827-11-0;NSC133827;DTXSID50299947;NSC-133827

Suppliers and Price of Hexanedioic acid, 2-(diethoxyphosphinyl)-, diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Hexanedioic acid, 2-(diethoxyphosphinyl)-, diethyl ester

Chemical Property:

Vapor Pressure:5.66E-07mmHg at 25°C
Boiling Point:411.3°Cat760mmHg
Flash Point:216°C
Density:1.113g/cm³
XLogP3:1.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:14
Exact Mass:338.14944019
Heavy Atom Count:22
Complexity:373

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)CCCC(C(=O)OCC)P(=O)(OCC)OCC

Technology Process of Hexanedioic acid, 2-(diethoxyphosphinyl)-, diethyl ester

There total 2 articles about Hexanedioic acid, 2-(diethoxyphosphinyl)-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 2969-81-5
Ethyl 4-bromobutyrate

: 66827-11-0
1,4-Bis-ethoxycarbonyl-butan-1-phosphonsaeure-diethylester

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 8h; Heating;
DOI:10.1016/S0040-4039(00)02238-3

Reference yield:

: 7209-01-0
diethyl 2-bromoadipate

: 122-52-1
triethyl phosphite

: 66827-11-0
1,4-Bis-ethoxycarbonyl-butan-1-phosphonsaeure-diethylester

Guidance literature:: at 150 - 160 ℃;
DOI:10.1246/bcsj.42.250

Reference yield:

: 66827-11-0
1,4-Bis-ethoxycarbonyl-butan-1-phosphonsaeure-diethylester

: (+/-)-homosarkomycin ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / potassium carbonate / tetrahydrofuran / 4 h / Heating

2: 81 percent / potassium carbonate / 16 h / 75 °C

3: 73 percent / t-BuOK / tetrahydrofuran / 2 h / 0 - 20 °C

4: 58 percent / aq. formaldehyde; potassium carbonate / tetrahydrofuran / 1 h / 20 °C

With formaldehyd; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; 1: Wittig-Horner reaction / 2: Michael addition;
DOI:10.1016/S0040-4039(00)02238-3