2-(diethoxy-phosphoryl)-3-oxo-cyclohexanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2-(diethoxy-phosphoryl)-3-oxo-cyclohexanecarboxylic acid ethyl ester
• CAS No.: 332180-78-6
• Molecular Formula: C₁₃H₂₃O₆P
• Molecular Weight: 306.296
• Mol file: 332180-78-6.mol

Synonyms:2-(diethoxy-phosphoryl)-3-oxo-cyclohexanecarboxylic acid ethyl ester

Chemical Property of 2-(diethoxy-phosphoryl)-3-oxo-cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 2-(diethoxy-phosphoryl)-3-oxo-cyclohexanecarboxylic acid ethyl ester

There total 3 articles about 2-(diethoxy-phosphoryl)-3-oxo-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(diethoxy-phosphorylmethyl)-hexanedioic acid diethyl ester (332180-76-4) → 2-(diethoxy-phosphoryl)-3-oxo-cyclohexanecarboxylic acid ethyl ester (332180-78-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1016/S0040-4039(00)02238-3

Reference yield:

2-Methylenhexandisaeure-diethylester (81143-48-8) → 2-(diethoxy-phosphoryl)-3-oxo-cyclohexanecarboxylic acid ethyl ester (332180-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / potassium carbonate / 16 h / 75 °C

2: 73 percent / t-BuOK / tetrahydrofuran / 2 h / 0 - 20 °C

With potassium tert-butylate; potassium carbonate; In tetrahydrofuran; 1: Michael addition;

DOI:10.1016/S0040-4039(00)02238-3

Reference yield:

1,4-Bis-ethoxycarbonyl-butan-1-phosphonsaeure-diethylester (66827-11-0) → 2-(diethoxy-phosphoryl)-3-oxo-cyclohexanecarboxylic acid ethyl ester (332180-78-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / potassium carbonate / tetrahydrofuran / 4 h / Heating

2: 81 percent / potassium carbonate / 16 h / 75 °C

3: 73 percent / t-BuOK / tetrahydrofuran / 2 h / 0 - 20 °C

With potassium tert-butylate; potassium carbonate; In tetrahydrofuran; 1: Wittig-Horner reaction / 2: Michael addition;

DOI:10.1016/S0040-4039(00)02238-3

upstream raw materials:

2-(diethoxy-phosphorylmethyl)-hexanedioic acid diethyl ester

2-Methylenhexandisaeure-diethylester

1,4-Bis-ethoxycarbonyl-butan-1-phosphonsaeure-diethylester