4-methyl-alpha-carboline

Base Information

• Chemical Name: 4-methyl-alpha-carboline
• CAS No.: 13174-97-5
• Molecular Formula: C₁₂H₁₀N₂
• Molecular Weight: 182.225
• Mol file: 13174-97-5.mol

Synonyms:1H-Pyrido[2,3-b]indole,4-methyl- (9CI); 9H-Pyrido[2,3-b]indole, 4-methyl- (8CI); 4-Methyl-a-carboline

Chemical Property of 4-methyl-alpha-carboline

Chemical Property:

• Vapor Pressure: 7.49E-06mmHg at 25°C
• Boiling Point: 387.2°Cat760mmHg
• Flash Point: 176.4°C
• PSA: 28.68000
• Density: 1.252g/cm³
• LogP: 3.02450

Purity/Quality:

99% ^*data from raw suppliers

4-methyl-9H-Pyrido[2,3-b]indole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methyl-alpha-carboline

There total 8 articles about 4-methyl-alpha-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-chloro-4-methyl-N-phenylpyridin-2-amine (1313869-85-0) → 4-Methyl-α-carbolin (13174-97-5)

Guidance literature:

With potassium tert-butylate; ammonia; for 1h; Inert atmosphere; Irradiation;

DOI:10.1021/jo200923n

Reference yield: 70.0%

9-methoxymethyl-4-methyl-9H-pyrido[2,3-b]indole → 4-Methyl-α-carbolin (13174-97-5)

Guidance literature:

With methanol; trifluorormethanesulfonic acid; trimethyl orthoformate; In nitromethane; at 100 ℃; for 1h;

DOI:10.3987/com-02-s(m)26

Reference yield: 62.0%

tert-butyl 3-((2Z)-4-(methoxyimino)but-2-en-2-yl)-1H-indole-1-carboxylate → 4-Methyl-α-carbolin (13174-97-5)

Guidance literature:

In 1,2-dichloro-benzene; at 240 ℃; for 3h; Sealed tube; Microwave irradiation;

DOI:10.1021/ol403191k

upstream raw materials:

1-(4-methylpyridin-2-yl)-1H-benzo[d][1,2,3]triazole

3-chloro-4-methyl-N-phenylpyridin-2-amine

2,3-dichloro-4-methylpyridine

aniline

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