Pyridine, 2,3-dichloro-4-methyl- (9CI)

Base Information

• Chemical Name: Pyridine, 2,3-dichloro-4-methyl- (9CI)
• CAS No.: 191419-07-5
• Molecular Formula: C₆H₅Cl₂N
• Molecular Weight: 162.018
• Hs Code.: 2933399090
• Mol file: 191419-07-5.mol

Synonyms:Pyridine,2,3-dichloro-4-methyl-(9CI);2,3-Dichloro-4-picoline;2,3,5-TRIFLUORO-4-TRIFLUOROMETHYL-PHENYLAMINE;

Chemical Property of Pyridine, 2,3-dichloro-4-methyl- (9CI)

Chemical Property:

• Vapor Pressure: 0.134mmHg at 25°C
• Refractive Index: 1.547
• Boiling Point: 224.789 °C at 760 mmHg
• PKA: 0.17±0.10(Predicted)
• Flash Point: 111.23 °C
• PSA: 12.89000
• Density: 1.319 g/cm³
• LogP: 2.69680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dichloro-4-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 2,3-dichloro-4-methyl- (9CI)

There total 1 articles about Pyridine, 2,3-dichloro-4-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,3-dichloro-pyridine (2402-77-9) + methyl iodide (74-88-4) → 2,3-dichloro-4-methylpyridine (191419-07-5)

Guidance literature:

2,3-dichloro-pyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1.16667h;

methyl iodide; In tetrahydrofuran; at -78 - -20 ℃; for 1h; regioselective reaction;

DOI:10.1021/jo200923n

Reference yield: 63.0%

6-(4-hydroxyphenyl)-1,5-dimethylpyrimidine-2,4(1H,3H)-dione + 2,3-dichloro-4-methylpyridine (191419-07-5) → 6-{4-[(3-chloro-4-methylpyridin-2-yl)oxy]phenyl}-1,5-dimethylpyrimidine-2,4{1H,3H}-dione

Guidance literature:

With caesium carbonate; at 140 ℃; for 48h;

Reference yield:

5-(4-hydroxy-2-methylphenyl)-4,6-dimethyl-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one (1609259-51-9) + 2,3-dichloro-4-methylpyridine (191419-07-5) → C24H26ClN3O3

Guidance literature:

With cesium fluoride; In dimethyl sulfoxide; at 80 ℃; for 6h;

upstream raw materials:

2,3-dichloro-pyridine

methyl iodide

Refernces

• 1、 Laha, Joydev K.,Barolo, Silvia M.,Rossi, Roberto A.,Cuny, Gregory D.. "Synthesis of carbolines by photostimulated cyclization of anilinohalopyridines". experimental part. p. 6421 - 6425. Retrieved 2011/09/15.