7-Chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid

Base Information

• Chemical Name: 7-Chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid
• CAS No.: 6338-16-5
• Molecular Formula: C16H9 Cl2 N O2
• Molecular Weight: 318.159
• NSC Number: 40402
• DSSTox Substance ID: DTXSID60285073
• Wikidata: Q82020310

Synonyms:7-chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid;6338-16-5;NSC40402;4-Quinolinecarboxylicacid, 7-chloro-2-(4-chlorophenyl)-;DTXSID60285073;NSC-40402;AKOS012770029

Chemical Property of 7-Chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 4.25E-11mmHg at 25°C
• Boiling Point: 506.9°Cat760mmHg
• Flash Point: 260.4°C
• Density: 1.456g/cm³
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 317.0010339
• Heavy Atom Count: 21
• Complexity: 385

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=NC3=C(C=CC(=C3)Cl)C(=C2)C(=O)O)Cl

Technology Process of 7-Chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid

There total 3 articles about 7-Chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloroisatin (6341-92-0) + para-chloroacetophenone (99-91-2) → 7-chloro-2-(4-chloro-phenyl)-quinoline-4-carboxylic acid (6338-16-5)

Guidance literature:

With water; potassium hydroxide; for 24h; Heating;

DOI:10.1016/j.bioorg.2021.105486

Reference yield:

4-chlorobenzaldehyde (104-88-1) + 3-chloro-aniline (108-42-9) → 7-chloro-2-(4-chloro-phenyl)-quinoline-4-carboxylic acid (6338-16-5) + 1-(3-chloro-phenyl)-5-(4-chloro-phenyl)-3-(3-chloro-phenylimino)-pyrrolidin-2-one (5450-03-3)

Guidance literature:

With ethanol; anschliessend Erwaermen mit Brenztraubensaeure;

DOI:10.1021/ja01213a041

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 7-chloro-2-(4-chloro-phenyl)-quinoline-4-carboxylic acid (6338-16-5) + 1-(3-chloro-phenyl)-5-(4-chloro-phenyl)-3-(3-chloro-phenylimino)-pyrrolidin-2-one (5450-03-3)

Guidance literature:

Anschliessendes Erwaermen mit Brenztraubensaeure;

DOI:10.1021/ja01213a041

upstream raw materials:

4-chlorobenzaldehyde

3-chloro-aniline

6-chloroisatin

para-chloroacetophenone

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