3-BROMO-4-METHOXYPHENYLACETIC ACID

Base Information

• Chemical Name: 3-BROMO-4-METHOXYPHENYLACETIC ACID
• CAS No.: 774-81-2
• Molecular Formula: C9H9BrO3
• Molecular Weight: 245.073
• Hs Code.: 2918990090
• Mol file: 774-81-2.mol

Synonyms:Aceticacid, (3-bromo-4-methoxyphenyl)- (6CI,7CI,8CI);2-(3-Bromo-4-methoxyphenyl)acetic acid;3-Bromo-4-methoxyphenylacetic acid;

Chemical Property of 3-BROMO-4-METHOXYPHENYLACETIC ACID

Chemical Property:

• Vapor Pressure: 7.62E-06mmHg at 25°C
• Melting Point: 115-117°C
• Refractive Index: 1.572
• Boiling Point: 361.1 °C at 760 mmHg
• PKA: 4.27±0.10(Predicted)
• Flash Point: 172.2 °C
• PSA: 46.53000
• Density: 1.56 g/cm³
• LogP: 2.08480
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromo-4-methoxyphenylacetic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-BROMO-4-METHOXYPHENYLACETIC ACID

There total 15 articles about 3-BROMO-4-METHOXYPHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-fluoro-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid + (3-bromo-4-methoxy-phenyl)-acetic acid (774-81-2)

Guidance literature:

Reference yield: 90.0%

methyl 2-(3-bromo-4-methoxyphenyl)acetate (19626-36-9) → (3-bromo-4-methoxy-phenyl)-acetic acid (774-81-2)

Guidance literature:

With sodium hydroxide; In methanol; for 1.5h; Ambient temperature;

DOI:10.1021/jo980860m

Reference yield:

4-methoxy-phenyl acetic acid methyl ester (23786-14-3) → (3-bromo-4-methoxy-phenyl)-acetic acid (774-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / Br₂, AlCl₃ / CH₂Cl₂ / 0.33 h / 0 °C

2: 90 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature

With sodium hydroxide; aluminium trichloride; bromine; In methanol; dichloromethane;

DOI:10.1021/jo980860m

upstream raw materials:

(3-bromo-4-methoxyphenyl)-acetonitrile

methyl 2-(3-bromo-4-methoxyphenyl)acetate

methyl 3-bromo-4-hydroxyphenylacetate

dimethyl sulfate

Downstream raw materials:

methyl 2-(3-bromo-4-methoxyphenyl)acetate

homoisovanillic acid

(3-bromo-4-methoxy-phenyl)-acetyl chloride

(S)-4-benzyl-3-(2-(3-bromo-4-methoxyphenyl)acetyl)oxazolidin-2-one

Refernces

• 1、 -. "NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION". Page/Page column 165. . Retrieved 2015/09/23.
• 2、 -. "2- [5- (5-carbamimidoyl-1H-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors". . . Retrieved 2008/06/13.