23786-14-3

Basic information

• Product Name: METHYL 4-METHOXYPHENYLACETATE
• Synonyms: Acetic acid, (p-methoxyphenyl)-, methyl ester;Acetic acid, 4-methoxyphenoxy, methyl ester;Methyl 2-(p-methoxyphenyl)acetate;Phenylacetic acid, 4-methoxy, methyl ester;4-METHOXYPHENYLACETIC ACID METHYL ESTER;ASISCHEM D13374;AURORA KA-6001;METHYL 4-METHOXYPHENYLACETATE
• CAS NO: 23786-14-3
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• EINECS: 245-886-1
• Product Categories: Aromatic Esters;C10 to C11;Carbonyl Compounds;Esters
• Mol File: 23786-14-3.mol
• Article Data: 115

Chemical Properties

• Boiling Point: 158 °C19 mm Hg(lit.)
• Flash Point: 98 °F
• Appearance: yellow-green/liquid
• Density: 1.135 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000151mmHg at 25°C
• Refractive Index: n20/D 1.516(lit.)
• Storage Temp.: Flammables area
• BRN: 2209665
• CAS DataBase Reference: METHYL 4-METHOXYPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-METHOXYPHENYLACETATE(23786-14-3)
• EPA Substance Registry System: METHYL 4-METHOXYPHENYLACETATE(23786-14-3)

Safety Data

• Statements: 10
• Safety Statements: 16-24/25
• RIDADR: UN 3272 3/PG 3
• WGK Germany: 3
• F: 10
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 23786-14-3(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to yellow liquid

Uses

Methyl 4-methoxyphenylacetate was used in the synthesis of 7,8-dihydroxy-2-(4′-hydroxybenzyl)-4H-1-benzopyran-4-one.

InChI:InChI=1/C10H12O4/c1-13-8-5-3-7(4-6-8)9(11)10(12)14-2/h3-6,9,11H,1-2H3

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 149-73-5 trimethyl orthoformate 
• 67-56-1 methanol 
• 21542-84-7 2-benzoylamino-3-(4-methoxy-phenyl)-acrylic acid 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 74-88-4 methyl iodide 
• 74-83-9 methyl bromide 
• 104-01-8 4-Methoxyphenylacetic acid 
• 162147-95-7 2-chloro-1-(4-methoxyphenyl)-2-(phenylsulfinyl)-1-ethanone 
• 113680-16-3 diethyl (2-(4-methoxyphenyl)-2-oxoethyl) phosphate 
• 6832-16-2 methyl diazoacetate 
• 100-66-3 methoxybenzene 
• 186581-53-3 diazomethane 
• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 53673-37-3 N-(2-amino-ethyl)-2-(4-methoxy-phenyl)-acetamide 
• 63732-96-7 17-(4-methoxy-phenethyl)-morphinan-3-ol 
• 68781-79-3 2-(4-Methoxy-phenyl)-3-oxo-succinic acid dimethyl ester 
• 71146-13-9 dimethyl 2-(4-methoxyphenyl)malonate 
• 104-01-8 4-Methoxyphenylacetic acid 
• 14062-18-1 ethyl p-methoxyphenylacetate 
• 15727-84-1 4'-Methoxyphenylessigsaeureallylester 
• 33155-61-2 tert-butyl 2-(4-methoxyphenyl)acetate 
• 92552-87-9 2-(4-methoxy-phenyl)-4H-benzo[1,4]thiazin-3-one 
• 137-07-5 2-amino-benzenethiol 
• 67031-10-1 methyl 2-(4-methoxyphenyl)pent-4-enoate 
• 216970-75-1 2-(4-methoxyphenyl)-3-oxo-3-(pyridin-4-yl)propionic acid methyl ester 
• 1026080-47-6 2-(4-methoxy-phenyl)-3-oxo-3-pyridazin-4-yl-propionic acid methyl ester 
• 561015-11-0 methyl 4-methoxy-2-(4-methoxyphenyl)-3-oxobutanoate 

Relevant articles and documents

syn-Selective Michael Reaction of α-Branched Aryl Acetaldehydes with Nitroolefins Promoted by Squaric Amino Acid Derived Bifunctional Br?nsted Bases

Here we describe a direct access to 2,2,3-trisubstituted syn γ-nitroaldehydes by addition of α-branched aryl acetaldehydes to nitroolefins promoted by a cinchona based squaric acid-derived amino acid peptide. Different α-methyl arylacetaldehydes react with β-aromatic and β-alkyl nitroolefins to afford the Michael adducts in high enantioselectivity and syn-selectivity. NMR experiments and DFT calculations predict the reaction to occur through the intermediacy of E-enolate. The interaction between the substrates and the catalyst follows Pápai's model, wherein an intramolecular H-bond interaction in the catalyst between the NH group of one of the tert-leucines and the squaramide oxygen seems to be key for discrimination of the corresponding reaction transition states.

B(C6F5)3-Catalyzed site-selective N1-alkylation of benzotriazoles with diazoalkanes

Alkylation of benzotriazoles is synthetically challenging, often leading to mixtures of N1 and N2 alkylation. Herein, metal-free catalytic site-selective N1-alkylation of benzotriazoles with diazoalkanes is described in the presence of 10 mol% of B(C6F5)3. These reactions provide N1-alkylated benzotriazoles in good to excellent yields and this protocol is successfully adapted to gram-scale syntheses as well as a derivative with antimicrobial activity.

SUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS T CELL ACTIVATORS

Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R4, R5, R6, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.