(2,6-Dimethoxyphenyl)lithium

Base Information

• Chemical Name: (2,6-Dimethoxyphenyl)lithium
• CAS No.: 2785-97-9
• Molecular Formula: C8H9 Li O2
• Molecular Weight: 144.099
• Hs Code.: 2909309090
• European Community (EC) Number: 220-502-5
• DSSTox Substance ID: DTXSID10950522
• Mol file: 2785-97-9.mol

Synonyms:2,6-Dimethoxyphenyl lithium;2785-97-9;(2,6-Dimethoxyphenyl)lithium;EINECS 220-502-5;lithium;1,3-dimethoxybenzene-2-ide;2,6-dimethoxyphenyllithium;C8H9LiO2;C8-H9-Li-O2;SCHEMBL1142161;DTXSID10950522;CWBYDEZPTKOCLA-UHFFFAOYSA-N;Lithium 2,6-dimethoxybenzen-1-ide;AKOS006274606

Chemical Property of (2,6-Dimethoxyphenyl)lithium

Chemical Property:

• Boiling Point: 217.5°Cat760mmHg
• Flash Point: 87.8°C
• PSA: 18.46000
• Density: g/cm³
• LogP: 1.50400
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 144.07625796
• Heavy Atom Count: 11
• Complexity: 183

Purity/Quality:

98%Min ^*data from raw suppliers

LITHIUM-2,6-DIMETHOXYPHENYL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [Li+].COC1=[C-]C(=CC=C1)OC

Technology Process of (2,6-Dimethoxyphenyl)lithium

There total 5 articles about (2,6-Dimethoxyphenyl)lithium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-bromo-2,6-dimethoxybenzene (16932-45-9) → (2,6-dimethoxyphenyl)lithium (2785-97-9)

Guidance literature:

With n-butyllithium; In hexane; pentane; at 20 ℃;

DOI:10.1021/ja3101787

Reference yield:

1,3-Dimethoxybenzene (151-10-0) → (2,6-dimethoxyphenyl)lithium (2785-97-9)

Guidance literature:

With phenyllithium;

Reference yield:

lithium 2,6-dimethoxybenzoate + carbon dioxide (124-38-9,18923-20-1) → (2,6-dimethoxyphenyl)lithium (2785-97-9) + 1,3-Dimethoxybenzene (151-10-0)

Guidance literature:

In hexane; toluene;

upstream raw materials:

1-bromo-2,6-dimethoxybenzene

1,3-Dimethoxybenzene

carbon dioxide

Downstream raw materials:

N-tert.-Butyl-N-(2,6-dimethoxy-phenyl)-hydroxylamin

2,6-Dimethoxyphenyl-t-butyl-nitroxid-Radikal

2,2',2'',6,6',6''-hexamethoxytriphenylmethanol

Bis-(2,6-dimethoxy-phenyl)-(2-methoxy-phenyl)-methanol

Refernces

• 1、 Heijnen, Dorus,Gualtierotti, Jean-Baptiste,Hornillos, Valentín,Feringa, Ben L.. "Nickel-Catalyzed Cross-Coupling of Organolithium Reagents with (Hetero)Aryl Electrophiles". supporting information. p. 3991 - 3995. Retrieved 2016/03/16.
• 2、 Neuwald, Boris,Caporaso, Lucia,Cavallo, Luigi,Mecking, Stefan. "Concepts for stereoselective acrylate insertion". supporting information. p. 1026 - 1036. Retrieved 2013/05/08.