5-Anilino-8-methyl-1,3-diphenyl-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-2,4,7-trione

Base Information

Chemical Name:5-Anilino-8-methyl-1,3-diphenyl-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-2,4,7-trione
CAS No.:177082-62-1
Molecular Formula:C₂₆H₂₀N₄O₃
Molecular Weight:436.47
Hs Code.:
DSSTox Substance ID:DTXSID50382964
Wikidata:Q82174469
ChEMBL ID:CHEMBL1350753

Synonyms:5-anilino-8-methyl-1,3-diphenyl-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-2,4,7-trione;5-anilino-8-methyl-1,3-diphenylpyrido[2,3-d]pyrimidine-2,4,7-trione;177082-62-1;Maybridge4_000402;Oprea1_398326;MLS000851142;CHEMBL1350753;SCHEMBL13163481;DTXSID50382964;HMS1522C06;HMS2811A06;IDI1_030984;NCGC00177618-01;SMR000457385;BRD-K69807870-001-01-6

Suppliers and Price of 5-Anilino-8-methyl-1,3-diphenyl-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-2,4,7-trione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Anilino-8-methyl-1,3-diphenyl-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-2,4,7-trione

Chemical Property:

Vapor Pressure:5.64E-13mmHg at 25°C
Boiling Point:569.3°C at 760 mmHg
Flash Point:298.1°C
Density:1.42g/cm³
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:436.15354051
Heavy Atom Count:33
Complexity:861

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)C=C(C2=C1N(C(=O)N(C2=O)C3=CC=CC=C3)C4=CC=CC=C4)NC5=CC=CC=C5

Technology Process of 5-Anilino-8-methyl-1,3-diphenyl-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-2,4,7-trione

There total 4 articles about 5-Anilino-8-methyl-1,3-diphenyl-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-2,4,7-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 62-53-3
aniline

: 177082-54-1
8-methyl-1,3-diphenyl-5-(4-toluenesulfonyloxy)-pyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione

: 177082-62-1
8-Methyl-1,3-diphenyl-5-phenylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione

Guidance literature:: In isopropyl alcohol; for 12h; Heating;
DOI:10.1002/prac.19963380129

Reference yield:

: 66400-26-8
6-methylamino-1,3-diphenyl-1H-pyrimidine-2,4-dione

: 177082-62-1
8-Methyl-1,3-diphenyl-5-phenylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / diphenyl ether / 2 h / 220 - 250 °C

2: 93 percent / Et₃N / acetonitrile / Heating

3: 91 percent / propan-2-ol / 12 h / Heating

With triethylamine; In diphenylether; isopropyl alcohol; acetonitrile;
DOI:10.1002/prac.19963380129

Reference yield:

: 177082-44-9
5-hydroxy-8-methyl-1,3-diphenyl-pyrido<2,3-d>pyrimidine-2,4,7-trione

: 177082-62-1
8-Methyl-1,3-diphenyl-5-phenylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / Et₃N / acetonitrile / Heating

2: 91 percent / propan-2-ol / 12 h / Heating

With triethylamine; In isopropyl alcohol; acetonitrile;
DOI:10.1002/prac.19963380129