(4-fluorophenyl)(naphthalen-2-yl)methanone

Base Information

Chemical Name:(4-fluorophenyl)(naphthalen-2-yl)methanone
CAS No.:1543-56-2
Molecular Formula:C17H11 F O
Molecular Weight:250.272
Hs Code.:
Mol file:1543-56-2.mol

Synonyms:Ketone, p-fluorophenyl 2-naphthyl(6CI,8CI); 4-Fluorophenyl 2-naphthyl ketone; NSC409627

Suppliers and Price of (4-fluorophenyl)(naphthalen-2-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of (4-fluorophenyl)(naphthalen-2-yl)methanone

Chemical Property:

Vapor Pressure:1.11E-06mmHg at 25°C
Boiling Point:402.3°Cat760mmHg
Flash Point:180.1°C
Density:1.215g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4-fluorophenyl)(naphthalen-2-yl)methanone

There total 7 articles about (4-fluorophenyl)(naphthalen-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 580-13-2
2-bromonaphthalene

: 459-57-4
4-fluorobenzaldehyde

: 1543-56-2
4-fluorophenyl 2-naphthyl ketone

Guidance literature:: 2-bromonaphthalene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

4-fluorobenzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;

With iodine; potassium carbonate; In tert-butyl alcohol; for 16h; Reflux;
DOI:10.1016/j.tet.2011.12.023

Reference yield: 61.0%

: 462-06-6
fluorobenzene

: 2243-83-6
2-naphthaloyl chloride

: 1813-64-5
2-(3-fluorobenzoyl)naphthalene

: 1543-60-8
2-(2-fluorobenzoyl)naphthalene

: 1543-56-2
4-fluorophenyl 2-naphthyl ketone

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at 40 ℃; for 4h;
DOI:10.1007/s11224-019-01368-z

Reference yield:

: 642-29-5
1-benzoylnaphthalene

: 1543-56-2
4-fluorophenyl 2-naphthyl ketone

Guidance literature:: Multi-step reaction with 3 steps

1: polyphosphoric acid / 6 h / 140 °C

2: aluminum (III) chloride / dichloromethane

3: polyphosphoric acid / 6 h / 240 °C

With aluminum (III) chloride; In dichloromethane; 2: |Friedel-Crafts Acylation;
DOI:10.1007/s11224-019-01368-z