1-(2,4-difluorophenyl)-6-fluoro-5-methyl-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

• Chemical Name: 1-(2,4-difluorophenyl)-6-fluoro-5-methyl-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• CAS No.: 146981-12-6
• Molecular Formula: C₂₂H₂₀F₃N₃O₃
• Molecular Weight: 431.414
• Mol file: 146981-12-6.mol

Synonyms:

Chemical Property of 1-(2,4-difluorophenyl)-6-fluoro-5-methyl-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 2.55E-17mmHg at 25°C
• Boiling Point: 641.2°Cat760mmHg
• Flash Point: 341.6°C
• Density: 1.397g/cm³

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(2,4-difluorophenyl)-6-fluoro-5-methyl-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 2 articles about 1-(2,4-difluorophenyl)-6-fluoro-5-methyl-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(RS)-2-methylpiperazine (109-07-9) + ethyl 6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylate (119916-37-9) → 6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (125290-60-0,146981-12-6)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) CH₃CN, reflux, 18 h, 2.) 3 h;

DOI:10.1021/jm00107a040

Reference yield:

→ 6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (125290-60-0,146981-12-6)

Guidance literature:

upstream raw materials:

(RS)-2-methylpiperazine

ethyl 6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylate

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