Abt-751

Base Information

Chemical Name:Abt-751
CAS No.:857447-92-8
Molecular Formula:C₁₈H₁₇N₃O₄S
Molecular Weight:371.417
Hs Code.:
European Community (EC) Number:689-192-0
NSC Number:742134
UNII:WDT5V5OB9F
DSSTox Substance ID:DTXSID60869913
Nikkaji Number:J497.061F
Wikidata:Q27166810
NCI Thesaurus Code:C2679
Metabolomics Workbench ID:153277
ChEMBL ID:CHEMBL20684
Mol file:857447-92-8.mol

Synonyms:E 7010;E-7010;E7010;N-(2-((4-hydroxyphenyl)amino)-3-pyridinyl)-4-methoxybenzenesulfonamide

Suppliers and Price of Abt-751

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ABT 751
10mg
$ 495.00

Tocris
ABT751 ≥98%(HPLC)
50
$ 734.00

Total 2 raw suppliers

Chemical Property of Abt-751

Chemical Property:

Vapor Pressure:9.51E-13mmHg at 25°C
Boiling Point:551°C at 760 mmHg
Flash Point:287°C
PSA：108.93000
Density:1.427g/cm³
LogP:4.56700
XLogP3:2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:371.09397721
Heavy Atom Count:26
Complexity:523

Purity/Quality:

97% ^*data from raw suppliers

ABT 751 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O
Recent ClinicalTrials:ABT-751 With Chemotherapy for Relapsed Pediatric ALL
Recent EU Clinical Trials:A Phase 2 Study Evaluating the Safety and Efficacy of ABT-751 in Combination with Docetaxel Versus Docetaxel Alone in Subjects with Advanced or Metastatic Non-Small Cell Lung Cancer
Uses ABT 751 is a microtubule inhibiitor that induces antitumor activity through induction of reactive oxygen species against mutidrug-resistant recurrent neuroblastoma xenograft mouse models when combined and used synergistically with fenretinide.

Technology Process of Abt-751

There total 5 articles about Abt-751 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78750-68-2
4-[(3-Amino-pyridin-2-yl)amino]phenol

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 141430-65-1,857447-92-8
N-[2-(4-hydroxy-phenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1021/jm00091a018

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 141430-65-1,857447-92-8
N-[2-(4-hydroxy-phenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 °C

2: H₂

3: pyridine / Ambient temperature

With pyridine; hydrogen;
DOI:10.1021/jm00091a018

Reference yield:

: 123-30-8
4-amino-phenol

: 141430-65-1,857447-92-8
N-[2-(4-hydroxy-phenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 °C

2: H₂

3: pyridine / Ambient temperature

With pyridine; hydrogen;
DOI:10.1021/jm00091a018