3-Phenyl-5-(hydroxymethyl)oxazolidine-2-one

Base Information

• Chemical Name: 3-Phenyl-5-(hydroxymethyl)oxazolidine-2-one
• CAS No.: 29218-21-1
• Molecular Formula: C10H11 N O3
• Molecular Weight: 193.202
• Hs Code.: 2934999090
• Mol file: 29218-21-1.mol

Synonyms:3-Phenyl-5-(hydroxymethyl)-2-oxazolidinone;5-(hydroxymethyl)-3-phenyl-1,3-oxazolidin-2-one

Chemical Property of 3-Phenyl-5-(hydroxymethyl)oxazolidine-2-one

Chemical Property:

• Vapor Pressure: 8.8E-05mmHg at 25°C
• Boiling Point: 326.4°Cat760mmHg
• Flash Point: 151.2°C
• PSA: 49.77000
• Density: 1.287g/cm³
• LogP: 1.06910

Purity/Quality:

99% ^*data from raw suppliers

5-HYDROXYMETHYL-3-PHENYL-2-OXAZOLIDINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phenyl-5-(hydroxymethyl)oxazolidine-2-one

There total 17 articles about 3-Phenyl-5-(hydroxymethyl)oxazolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(2-oxiranylmethyl)aniline (10525-86-7) + carbon dioxide (124-38-9,18923-20-1) → 5-(hydroxymethyl)-3-phenyl-2-oxooxazolidine (29218-21-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 20h;

Reference yield: 93.0%

carbon dioxide (124-38-9,18923-20-1) + N-(3-chloro-2-hydroxypropyl)aniline (76226-32-9,15949-12-9) → 5-(hydroxymethyl)-3-phenyl-2-oxooxazolidine (29218-21-1)

Guidance literature:

With tetrabutylammomium bromide; caesium carbonate; In methanol; at 50 ℃; for 24h;

DOI:10.1039/d1cc02493k

Reference yield: 85.0%

1-phenylamino 2,3-propanediol (5840-15-3) + carbon dioxide (124-38-9,18923-20-1) → 5-hydroxy-3-phenyl-1,3-oxazinan-2-one (67959-75-5) + 5-(hydroxymethyl)-3-phenyl-2-oxooxazolidine (29218-21-1)

Guidance literature:

With caesium carbonate; p-toluenesulfonyl chloride; In acetone; at 0 - 20 ℃; for 20h; under 3750.38 Torr; chemoselective reaction; Autoclave; Sealed tube;

DOI:10.1039/c8cc00636a

upstream raw materials:

ethyl acetoacetate

1-phenylamino 2,3-propanediol

Diethyl carbonate

carbon monoxide

Downstream raw materials:

5-carbamoyloxymethyl-3-phenyl-oxazolidin-2-one

1-[(4-Cyano-5-methyl-4-phenyl)hexyl]-4-[(3-phenyl-2-oxo-5-oxazolidinyl)methyl]piperazine

5-[(4-tert-butylphenoxy)methyl]-3-phenyl-1,3-oxazolidin-2-one

C₁₈H₁₉NO₃