1-(2-Ethoxyphenyl)piperazine

Base Information

• Chemical Name: 1-(2-Ethoxyphenyl)piperazine
• CAS No.: 13339-01-0
• Molecular Formula: C12H18N2O
• Molecular Weight: 206.288
• Hs Code.: 2933599090
• European Community (EC) Number: 280-190-1,236-389-0
• DSSTox Substance ID: DTXSID40928092
• Nikkaji Number: J213.856E
• Wikidata: Q72471973
• ChEMBL ID: CHEMBL273923
• Mol file: 13339-01-0.mol

Synonyms:1-(2-Ethoxyphenyl)piperazine;13339-01-0;1-(2-Ethoxy-phenyl)-piperazine;Piperazine,1-(2-ethoxyphenyl)-;CHEMBL273923;EINECS 236-389-0;EINECS 280-190-1;1-(2-Ethoxyphenyl)piperazinium chloride;H04;D03NWV;Oprea1_356570;4(2-eth-oxyphenyl)piperazine;SCHEMBL255189;N-(2-ethoxyphenyl)-piperazine;1-(2-ethoxyphenyl)-piperazine;N-(2-ethyoxyphenyl)-piperazine;1-(2-Ethoxyphenyl)piperazine #;DTXSID40928092;Piperazine, 1-(2-ethoxyphenyl)-;BDBM50017454;MFCD01026120;NSC 28773;STK374779;AKOS005447346;AB07986;FS-1657;1-(2-Ethoxyphenyl)piperazine, AldrichCPR;A2836;CS-0444882;FT-0714641;(4-Benzyl-6-methyl-morpholin-2-yl)-methanol

Chemical Property of 1-(2-Ethoxyphenyl)piperazine

Chemical Property:

• Boiling Point: 344.663 °C at 760 mmHg
• Flash Point: 162.246 °C
• PSA: 24.50000
• Density: 1.041 g/cm³
• LogP: 1.88870
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 206.141913202
• Heavy Atom Count: 15
• Complexity: 181

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Ethoxyphenyl)piperazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1N2CCNCC2

Technology Process of 1-(2-Ethoxyphenyl)piperazine

There total 4 articles about 1-(2-Ethoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(2-ethoxyphenyl)piperazine monohydrochloride (83081-75-8) → 1-(2-ethoxyphenyl)piperazine (13339-01-0)

Guidance literature:

With macroporous triethylammonium methylpolystyrene carbonate; In methanol; at 3 ℃;

DOI:10.1016/j.bcp.2005.10.023

Reference yield: 83.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + ortho-phenitidine (94-70-2) → 1-(2-ethoxyphenyl)piperazine (13339-01-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 140 ℃;

Reference yield:

bis(2-bromoethyl)amine hydrobromide (43204-63-3) + ortho-phenitidine (94-70-2) → 1-(2-ethoxyphenyl)piperazine (13339-01-0)

Guidance literature:

With methanol;

DOI:10.1021/jo01103a024

upstream raw materials:

bis(2-bromoethyl)amine hydrobromide

ortho-phenitidine

1-(2-ethoxyphenyl)piperazine monohydrochloride

bis-(2-chloroethyl)amine hydrochloride

Downstream raw materials:

3-[4-(2-ethoxy-phenyl)-piperazin-1-ylmethyl]-2,9-dihydro-2,4,9-triaza-fluoren-1-one

Refernces

• 1、 -. "THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS". Paragraph 00378. . Retrieved 2017/09/05.