43204-63-3

Basic information

• Product Name: bis(2-bromoethyl)ammonium bromide
• Synonyms: bis(2-bromoethyl)ammonium bromide;BIS(2-BROMOETHYL)AMINEHYDROBROMICACIDSALT;2-BROMO-N-(2-BROMOETHYL)ETHANAMINE HYDROBROMIDE;Bis(2-bromoethyl)amine·hydrobrominate;Bis(2-bromoethyl)amine hydrobromide;EthanaMine, 2-broMo-N-(2-broMoethyl)-, hydrobroMide;2,2'-Dibromodiethylamine Hydrobromide;Bis(2-bromoethyl)ammonium hydrobromide
• CAS NO: 43204-63-3
• Molecular Formula: 2BrH*C₄H₉Br₂N
• Molecular Weight: 311.8409
• EINECS: 256-142-0
• Mol File: 43204-63-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 203-205℃
• Boiling Point: 239.4°C at 760mmHg
• Flash Point: 98.6°C
• Appearance: /
• Density: 1.779g/cm³
• Vapor Pressure: 0.0402mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: bis(2-bromoethyl)ammonium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: bis(2-bromoethyl)ammonium bromide(43204-63-3)
• EPA Substance Registry System: bis(2-bromoethyl)ammonium bromide(43204-63-3)

Safety Data

• Hazardous Substances Data: 43204-63-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 43204-63-3 differently. You can refer to the following data:
1. Bis(2-bromoethyl)amine hydrobromide is used in the synthesis of quinone phosphorodiamidate drugs that target DT-diaphorase, an enzyme that is overexpressed in solid tumors. Also used in the preparat ion of anti-depressive drugs, in the treatment of major depressive disorders. Trazadone Impurity.
2. 2,2''-Dibromodiethylamine Hydrobromide is used in the synthesis of quinone phosphorodiamidate drugs that target DT-diaphorase, an enzyme that is overexpressed in solid tumors. Also used in the preparation of anti-depressive drugs, in the treatment of major depressive disorders. Trazadone Impurity.

InChI:InChI=1/C4H9Br2N/c5-1-3-7-4-2-6/h7H,1-4H2

Upstream product

• 2488-95-1 1,2-bis(2'-hydroxyethyl)-hydrazine 
• 111-42-2 2,2'-iminobis[ethanol] 
• 78265-92-6 1-Phthalyl-2,2-di(2-bromethyl)hydrazin 

Downstream Products

• 101266-21-1 1-(2-allylmercapto-phenyl)-piperazine 
• 40818-92-6 1-(2-ethylmercapto-phenyl)-piperazine 
• 57536-86-4 1-naphtylpiperazine 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 1013-24-7 1-(2-methylsulfanylphenyl)piperazine 
• 39593-08-3 (4-methylphenyl)piperazine 
• 6269-89-2 1-(4-Nitrophenyl)piperazine 
• 92-54-6 4-phenyl-1-piperazine 
• 4432-90-0 bis(2-phenylaminoethyl)amine 
• 13339-02-1 1-(2-aminophenyl)piperazine 
• 57536-91-1 1-naphthalen-2-yl-piperazine 
• 39512-51-1 1-(o-toluyl)piperazine 
• 131636-34-5 phenyl N,N-bis(2-bromoethyl)phosphoramidate chloride 
• 189323-09-9 benzyl bis(2-bromoethyl)carbamate 

Relevant articles and documents

Development of novel quinone phosphorodiamidate prodrugs targeted to DT-diaphorase

A series of naphthoquinone and benzimidazolequinone phosphorodiamidates has been synthesized and studied as potential cytotoxic prodrugs activated by DT-diaphorase. Reduction of the quinone moiety in the target compounds was expected to provide a pathway for expulsion of the phosphoramide mustard alkylating agent. All of the compounds synthesized were excellent substrates for purified human DT-diaphorase (k(cat)/K(m) = 3 x 107 - 3 x 108 M-1 s-1). The naphthoquinones were toxic to both HT-29 and BE human colon cancer cell lines in a clonogenic assay; however, cytotoxicity did not correlate with DT-diaphorase activity in these cell lines. The benzimidazolequinone analogues were 1-2 orders of magnitude less cytotoxic than the naphthoquinone analogues. Chemical reduction of the naphthoquinone led to rapid expulsion of the phosphorodiamidate anion; in contrast, the benzimidazole reduction product was stable. Michael addition of glutathione and other sulfur nucleophiles provides an alternate mechanism for activation of the naphthoquinone phosphorodiamidates, and this mechanism may contribute to the cytotoxicity of these compounds.

Tricyclic analgesics

A tricyclic compound of Formula (I): wherein: R1 is hydrogen or hydroxy; R2 is hydrogen or hydroxy; or R1 and R2 together are oxygen; A is a bond, CH2, CH CH3, CH2 CH2 or C(CH3)2; R3 and R4 are the same or different and are hydrogen, halo, C1-C6 alkyl, C1-C4 alkoxy, trifluoromethyl NO2, COR6, COOR6 or NR6R7, wherein R6 and R7 are the same or different and are hydrogen, C1-C6 alkyl or benzyl; R5 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, (O═C)—C1-6 alkyl, (O═C)—C2-6 alkenyl, (O═C)—C3-6 cycloalkyl wherein said alkyl, alkenyl and cycloalkyl groups can be substituted by 1, 2 or 3 groups selected from halo, C3-C6 cycloalkyl, phenyl or substituted phenyl, and salts thereof, are particularly useful for treating, among other indications, neuropathic pain and other CNS disorders.

Synthese von N,N-Di(2-bromethyl)hydrazin

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