2-BROMO-4,5-DIMETHOXYBENZOIC ACID

Base Information

• Chemical Name: 2-BROMO-4,5-DIMETHOXYBENZOIC ACID
• CAS No.: 6286-46-0
• Molecular Formula: C9H9BrO4
• Molecular Weight: 261.072
• Hs Code.: 29189900
• Mol file: 6286-46-0.mol

Synonyms:Veratricacid, 6-bromo- (6CI);2-Bromo-4,5-dimethoxybenzoic acid;6-Bromoveratric acid;NSC 10074;

Chemical Property of 2-BROMO-4,5-DIMETHOXYBENZOIC ACID

Chemical Property:

• Appearance/Colour: off-white crystalline solid
• Vapor Pressure: 4.05E-05mmHg at 25°C
• Melting Point: 188-190 °C(lit. )
• Refractive Index: 1.566
• Boiling Point: 337.6 °C at 760 mmHg
• PKA: 3.00±0.10(Predicted)
• Flash Point: 158 °C
• PSA: 55.76000
• Density: 1.571 g/cm³
• LogP: 2.16450
• Storage Temp.: Room temperature.
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4,5-dimethoxybenzoic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Bromo-4,5-dimethoxybenzoic acid may be used as starting material for the synthesis of norathyriol and urolithins.

Technology Process of 2-BROMO-4,5-DIMETHOXYBENZOIC ACID

There total 27 articles about 2-BROMO-4,5-DIMETHOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.45%

methyl 6-bromo-3,4-dimethoxybenzoate (17667-32-2) → 2-bromo-4,5-dimethoxybenzoic acid (6286-46-0)

Guidance literature:

With water; potassium hydroxide; for 2h; Reflux;

Reference yield: 91.6%

Veratric acid (93-07-2) → 2-bromo-4,5-dimethoxybenzoic acid (6286-46-0)

Guidance literature:

Veratric acid; With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium hydroxide; In water; at 0 - 5 ℃;

With hydrogenchloride; sodium sulfite; In water; toluene; at 70 ℃; for 1h; Concentration; Reagent/catalyst; Temperature;

Reference yield: 88.3%

3,4-dimethylbenzoic acid (619-04-5) → 2-bromo-4,5-dimethoxybenzoic acid (6286-46-0)

Guidance literature:

3,4-dimethylbenzoic acid; With bromine; sodium hydroxide; In water; at 0 - 5 ℃; for 1h;

With hydrogenchloride; sodium sulfite; In water; toluene; at 70 ℃; for 1h;

upstream raw materials:

2-bromo-4,5-dimethoxybenzaldehyde

methyl 6-bromo-3,4-dimethoxybenzoate

1-bromo-4,5-dimethoxy-2-methylbenzene

2-bromo-4,5-dimethoxybenzonitrile

Downstream raw materials:

methyl 6-bromo-3,4-dimethoxybenzoate

1-bromo-4,5-dimethoxy-2-nitro-benzene

2-bromo-5-hydroxy-4-methoxybenzoic acid

2-bromo-4,5-dimethoxybenzoyl chloride